Nucleolar RNA helicase 2 (EC 3.6.4.13) (DEAD box protein 21) (Gu-alpha) (Nucleolar RNA helicase Gu) (Nucleolar RNA helicase II) (RH II/Gu)
1_MPGKL 6_ RSDAG 11_ LESDT 16_ AMKKG 21_ ETLRK 26_ QTEEK 31_ EKKEK 36_ PKSDK 41_ TEEIA 46_ EEEET 51_ VFPKA 56_ KQVKK 61_ KAEPS 66_ EVDMN 71_ SPKSK 76_ KAKKK 81_ EEPSQ 86_ NDISP 91_ KTKSL 96_ RKKKE 101_ PIEKK 106_ VVSSK 111_ TKKVT 116_ KNEEP 121_ SEEEI 126_ DAPKP 131_ KKMKK 136_ EKEMN 141_ GETRE 146_ KSPKL 151_ KNGFP 156_ HPEPD 161_ CNPSE 166_ AASEE 171_ SNSEI 176_ EQEIP 181_ VEQKE 186_ GAFSN 191_ FPISE 196_ ETIKL 201_ LKGRG 206_ VTFLF 211_ PIQAK 216_ TFHHV 221_ YSGKD 226_ LIAQA 231_ RTGTG 236_ KTFSF 241_ AIPLI 246_ EKLHG 251_ ELQDR 256_ KRGRA 261_ PQVLV 266_ LAPTR 271_ ELANQ 276_ VSKDF 281_ SDITK 286_ KLSVA 291_ CFYGG 296_ TPYGG 301_ QFERM 306_ RNGID 311_ ILVGT 316_ PGRIK 321_ DHIQN 326_ GKLDL 331_ TKLKH 336_ VVLDE 341_ VDQML 346_ DMGFA 351_ DQVEE 356_ ILSVA 361_ YKKDS 366_ EDNPQ 371_ TLLFS 376_ ATCPH 381_ WVFNV 386_ AKKYM 391_ KSTYE 396_ QVDLI 401_ GKKTQ 406_ KTAIT 411_ VEHLA 416_ IKCHW 421_ TQRAA 426_ VIGDV 431_ IRVYS 436_ GHQGR 441_ TIIFC 446_ ETKKE 451_ AQELS 456_ QNSAI 461_ KQDAQ 466_ SLHGD 471_ IPQKQ 476_ REITL 481_ KGFRN 486_ GSFGV 491_ LVATN 496_ VAARG 501_ LDIPE 506_ VDLVI 511_ QSSPP 516_ KDVES 521_ YIHRS 526_ GRTGR 531_ AGRTG 536_ VCICF 541_ YQHKE 546_ EYQLV 551_ QVEQK 556_ AGIKF 561_ KRIGV 566_ PSATE 571_ IIKAS 576_ SKDAI 581_ RLLDS 586_ VPPTA 591_ ISHFK 596_ QSAEK 601_ LIEEK 606_ GAVEA 611_ LAAAL 616_ AHISG 621_ ATSVD 626_ QRSLI 631_ NSNVG 636_ FVTMI 641_ LQCSI 646_ EMPNI 651_ SYAWK 656_ ELKEQ 661_ LGEEI 666_ DSKVK 671_ GMVFL 676_ KGKLG 681_ VCFDV 686_ PTASV 691_ TEIQE 696_ KWHDS 701_ RRWQL 706_ SVATE 711_ QPELE 716_ GPREG 721_ YGGFR 726_ GQREG 731_ SRGFR 736_ GQRDG 741_ NRRFR 746_ GQREG 751_ SRGPR 756_ GQRSG 761_ GGNKS 766_ NRSQN 771_ KGQKR 776_SFSKA
1: RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060, PubMed:28790157). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as a cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Together with SIRT7, required to prevent R-loop-associated DNA damage and transcription-associated genomic instability: deacetylation by SIRT7 activates the helicase activity, thereby overcoming R-loop-mediated stalling of RNA polymerases (PubMed:28790157). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity)