Sialic acid synthase (N-acetylneuraminate synthase) (EC 2.5.1.56) (N-acetylneuraminate-9-phosphate synthase) (EC 2.5.1.57) (N-acetylneuraminic acid phosphate synthase) (N-acetylneuraminic acid synthase)
1_MPLEL 6_ ELCPG 11_ RWVGG 16_ QHPCF 21_ IIAEI 26_ GQNHQ 31_ GDLDV 36_ AKRMI 41_ RMAKE 46_ CGADC 51_ AKFQK 56_ SELEF 61_ KFNRK 66_ ALERP 71_ YTSKH 76_ SWGKT 81_ YGEHK 86_ RHLEF 91_ SHDQY 96_ RELQR 101_ YAEEV 106_ GIFFT 111_ ASGMD 116_ EMAVE 121_ FLHEL 126_ NVPFF 131_ KVGSG 136_ DTNNF 141_ PYLEK 146_ TAKKG 151_ RPMVI 156_ SSGMQ 161_ SMDTM 166_ KQVYQ 171_ IVKPL 176_ NPNFC 181_ FLQCT 186_ SAYPL 191_ QPEDV 196_ NLRVI 201_ SEYQK 206_ LFPDI 211_ PIGYS 216_ GHETG 221_ IAISV 226_ AAVAL 231_ GAKVL 236_ ERHIT 241_ LDKTW 246_ KGSDH 251_ SASLE 256_ PGELA 261_ ELVRS 266_ VRLVE 271_ RALGS 276_ PTKQL 281_ LPCEM 286_ ACNEK 291_ LGKSV 296_ VAKVK 301_ IPEGT 306_ ILTMD 311_ MLTVK 316_ VGEPK 321_ GYPPE 326_ DIFNL 331_ VGKKV 336_ LVTVE 341_ EDDTI 346_ MEELV 351_DNHGK
1: Catalyzes the condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) (PubMed:10749855). Also catalyzes the condensation of PEP and D-mannose 6-phosphate (Man-6-P) to produce 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate (KDN-9-P) (PubMed:10749855). Neu5Ac-9-P and KDN-9-P are the phosphorylated forms of sialic acids N-acetylneuraminic acid (Neu5Ac) and deaminoneuraminic acid (KDN), respectively (PubMed:10749855). Required for brain and skeletal development (PubMed:27213289)