Translation initiation factor eIF-2B subunit gamma (eIF-2B GDP-GTP exchange factor subunit gamma)
1_MEFQA 6_ VVMAV 11_ GGGSR 16_ MTDLT 21_ SSIPK 26_ PLLPV 31_ GNKPL 36_ IWYPL 41_ NLLER 46_ VGFEE 51_ VIVVT 56_ TRDVQ 61_ KALCA 66_ EFKMK 71_ MKPDI 76_ VCIPD 81_ DADMG 86_ TADSL 91_ RYIYP 96_ KLKTD 101_ VLVLS 106_ CDLIT 111_ DVALH 116_ EVVDL 121_ FRAYD 126_ ASLAM 131_ LMRKG 136_ QDSIE 141_ PVPGQ 146_ KGKKK 151_ AVEQR 156_ DFIGV 161_ DSTGK 166_ RLLFM 171_ ANEAD 176_ LDEEL 181_ VIKGS 186_ ILQKH 191_ PRIRF 196_ HTGLV 201_ DAHLY 206_ CLKKY 211_ IVDFL 216_ MENGS 221_ ITSIR 226_ SELIP 231_ YLVRK 236_ QFSSA 241_ SSQQG 246_ QEEKE 251_ EDLKK 256_ KELKS 261_ LDIYS 266_ FIKEA 271_ NTLNL 276_ APYDA 281_ CWNAC 286_ RGDRW 291_ EDLSR 296_ SQVRC 301_ YVHIM 306_ KEGLC 311_ SRVST 316_ LGLYM 321_ EANRQ 326_ VPKLL 331_ SALCP 336_ EEPPV 341_ HSSAQ 346_ IVSKH 351_ LVGVD 356_ SLIGP 361_ ETQIG 366_ EKSSI 371_ KRSVI 376_ GSSCL 381_ IKDRV 386_ TITNC 391_ LLMNS 396_ VTVEE 401_ GSNIQ 406_ GSVIC 411_ NNAVI 416_ EKGAD 421_ IKDCL 426_ IGSGQ 431_ RIEAK 436_ AKRVN 441_ EVIVG 446_NDQLM
1: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492)