Muscleblind-like protein 1 (Triplet-expansion RNA-binding protein)
1_MAVSV 6_ TPIRD 11_ TKWLT 16_ LEVCR 21_ EFQRG 26_ TCSRP 31_ DTECK 36_ FAHPS 41_ KSCQV 46_ ENGRV 51_ IACFD 56_ SLKGR 61_ CSREN 66_ CKYLH 71_ PPPHL 76_ KTQLE 81_ INGRN 86_ NLIQQ 91_ KNMAM 96_ LAQQM 101_ QLANA 106_ MMPGA 111_ PLQPV 116_ PMFSV 121_ APSLA 126_ TNASA 131_ AAFNP 136_ YLGPV 141_ SPSLV 146_ PAEIL 151_ PTAPM 156_ LVTGN 161_ PGVPV 166_ PAAAA 171_ AAAQK 176_ LMRTD 181_ RLEVC 186_ REYQR 191_ GNCNR 196_ GENDC 201_ RFAHP 206_ ADSTM 211_ IDTND 216_ NTVTV 221_ CMDYI 226_ KGRCS 231_ REKCK 236_ YFHPP 241_ AHLQA 246_ KIKAA 251_ QYQVN 256_ QAAAA 261_ QAAAT 266_ AAAMT 271_ QSAVK 276_ SLKRP 281_ LEATF 286_ DLGIP 291_ QAVLP 296_ PLPKR 301_ PALEK 306_ TNGAT 311_ AVFNT 316_ GIFQY 321_ QQALA 326_ NMQLQ 331_ QHTAF 336_ LPPVP 341_ MVHGA 346_ TPATV 351_ SAATT 356_ SATSV 361_ PFAAT 366_ ATANQ 371_ IPIIS 376_ AEHLT 381_SHKYV
1: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues. Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (PubMed:37548402). Regulates NCOR2 alternative splicing (By similarity)