Neutral ceramidase (N-CDase) (NCDase) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 2) (BCDase) (LCDase) (hCD) (N-acylsphingosine amidohydrolase 2) (Non-lysosomal ceramidase) [Cleaved into: Neutral ceramidase soluble form]
1_MAKRT 6_ FSNLE 11_ TFLIF 16_ LLVMM 21_ SAITV 26_ ALLSL 31_ LFITS 36_ GTIEN 41_ HKDLG 46_ GHFFS 51_ TTQSP 56_ PATQG 61_ STAAQ 66_ RSTAT 71_ QHSTA 76_ TQSST 81_ ATQTS 86_ PVPLT 91_ PESPL 96_ FQNFS 101_ GYHIG 106_ VGRAD 111_ CTGQV 116_ ADINL 121_ MGYGK 126_ SGQNA 131_ QGILT 136_ RLYSR 141_ AFIMA 146_ EPDGS 151_ NRTVF 156_ VSIDI 161_ GMVSQ 166_ RLRLE 171_ VLNRL 176_ QSKYG 181_ SLYRR 186_ DNVIL 191_ SGTHT 196_ HSGPA 201_ GYFQY 206_ TVFVI 211_ ASEGF 216_ SNQTF 221_ QHMVT 226_ GILKS 231_ IDIAH 236_ TNMKP 241_ GKIFI 246_ NKGNV 251_ DGVQI 256_ NRSPY 261_ SYLQN 266_ PQSER 271_ ARYSS 276_ NTDKE 281_ MIVLK 286_ MVDLN 291_ GDDLG 296_ LISWF 301_ AIHPV 306_ SMNNS 311_ NHLVN 316_ SDNVG 321_ YASYL 326_ LEQEK 331_ NKGYL 336_ PGQGP 341_ FVAAF 346_ ASSNL 351_ GDVSP 356_ NILGP 361_ RCINT 366_ GESCD 371_ NANST 376_ CPIGG 381_ PSMCI 386_ AKGPG 391_ QDMFD 396_ STQII 401_ GRAMY 406_ QRAKE 411_ LYASA 416_ SQEVT 421_ GPLAS 426_ AHQWV 431_ DMTDV 436_ TVWLN 441_ STHAS 446_ KTCKP 451_ ALGYS 456_ FAAGT 461_ IDGVG 466_ GLNFT 471_ QGKTE 476_ GDPFW 481_ DTIRD 486_ QILGK 491_ PSEEI 496_ KECHK 501_ PKPIL 506_ LHTGE 511_ LSKPH 516_ PWHPD 521_ IVDVQ 526_ IITLG 531_ SLAIT 536_ AIPGE 541_ FTTMS 546_ GRRLR 551_ EAVQA 556_ EFASH 561_ GMQNM 566_ TVVIS 571_ GLCNV 576_ YTHYI 581_ TTYEE 586_ YQAQR 591_ YEAAS 596_ TIYGP 601_ HTLSA 606_ YIQLF 611_ RNLAK 616_ AIATD 621_ TVANL 626_ SRGPE 631_ PPFFK 636_ QLIVP 641_ LIPSI 646_ VDRAP 651_ KGRTF 656_ GDVLQ 661_ PAKPE 666_ YRVGE 671_ VAEVI 676_ FVGAN 681_ PKNSV 686_ QNQTH 691_ QTFLT 696_ VEKYE 701_ ATSTS 706_ WQIVC 711_ NDASW 716_ ETRFY 721_ WHKGL 726_ LGLSN 731_ ATVEW 736_ HIPDT 741_ AQPGI 746_ YRIRY 751_ FGHNR 756_ KQDIL 761_ KPAVI 766_ LSFEG 771_TSPAF
1: Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH (PubMed:10781606, PubMed:16229686, PubMed:26190575). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:15946935, PubMed:19345744, PubMed:24798654). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (PubMed:11278489, PubMed:17475390). Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1-phosphate from the degradation of sphingomyelin, a sphingolipid enriched in the plasma membrane of cells (PubMed:16061940). Also participates in the hydrolysis of ceramides from the extracellular milieu allowing the production of sphingosine-1-phosphate inside and outside cells (By similarity). This is the case for instance with the digestion of dietary sphingolipids in the intestinal tract (By similarity)