Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor 1) (Asef) (Asef1)
1_MPWEE 6_ PAGEK 11_ PSCSH 16_ SQKAF 21_ HMEPA 26_ QKPCF 31_ TTDMV 36_ TWALL 41_ CISAE 46_ TVRGE 51_ APSQP 56_ RGIPH 61_ RSPVS 66_ VDDLW 71_ LEKTQ 76_ RKKLQ 81_ KQAHV 86_ ERRLH 91_ IGAVH 96_ KDGVK 101_ CWRKT 106_ IITSP 111_ ESLNL 116_ PRRSH 121_ PLSQS 126_ APTGL 131_ NHMGW 136_ PEHTP 141_ GTAMP 146_ DGALD 151_ TAVCA 156_ DEVGS 161_ EEDLY 166_ DDLHS 171_ SSHHY 176_ SHPGG 181_ GGEQL 186_ AINEL 191_ ISDGS 196_ VVCAE 201_ ALWDH 206_ VTMDD 211_ QELGF 216_ KAGDV 221_ IEVMD 226_ ATNRE 231_ WWWGR 236_ VADGE 241_ GWFPA 246_ SFVRL 251_ RVNQD 256_ EPADD 261_ DAPLA 266_ GNSGA 271_ EDGGA 276_ EAQSS 281_ KDQMR 286_ TNVIN 291_ EILST 296_ ERDYI 301_ KHLRD 306_ ICEGY 311_ VRQCR 316_ KRADM 321_ FSEEQ 326_ LRTIF 331_ GNIED 336_ IYRCQ 341_ KAFVK 346_ ALEQR 351_ FNRER 356_ PHLSE 361_ LGACF 366_ LEHQA 371_ DFQIY 376_ SEYCN 381_ NHPNA 386_ CVELS 391_ RLTKL 396_ SKYVY 401_ FFEAC 406_ RLLQK 411_ MIDIS 416_ LDGFL 421_ LTPVQ 426_ KICKY 431_ PLQLA 436_ ELLKY 441_ THPQH 446_ RDFKD 451_ VEAAL 456_ HAMKN 461_ VAQLI 466_ NERKR 471_ RLENI 476_ DKIAQ 481_ WQSSI 486_ EDWEG 491_ EDLLV 496_ RSSEL 501_ IYSGE 506_ LTRVT 511_ QPQAK 516_ SQQRM 521_ FFLFD 526_ HQLIY 531_ CKKDL 536_ LRRDV 541_ LYYKG 546_ RLDMD 551_ GLEVV 556_ DLEDG 561_ KDRDL 566_ HVSIK 571_ NAFRL 576_ HRGAT 581_ GDSHL 586_ LCTRK 591_ PEQKQ 596_ RWLKA 601_ FARER 606_ EQVQL 611_ DQETG 616_ FSITE 621_ LQRKQ 626_ AMLNA 631_ SKQQV 636_ TGKPK 641_ AVGRP 646_ CYLTR 651_ QKHPA 656_ LPSNR 661_ PQQQV 666_ LVLAE 671_ PRRKP 676_ STFWH 681_SISRL
1: Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression