Potassium voltage-gated channel subfamily KQT member 5 (KQT-like 5) (Potassium channel subunit alpha KvLQT5) (Voltage-gated potassium channel subunit Kv7.5)
1_MPRHH 6_ AGGEE 11_ GGAAG 16_ LWVKS 21_ GAAAA 26_ AAGGG 31_ RLGSG 36_ MKDVE 41_ SGRGR 46_ VLLNS 51_ AAARG 56_ DGLLL 61_ LGTRA 66_ ATLGG 71_ GGGGL 76_ RESRR 81_ GKQGA 86_ RMSLL 91_ GKPLS 96_ YTSSQ 101_ SCRRN 106_ VKYRR 111_ VQNYL 116_ YNVLE 121_ RPRGW 126_ AFIYH 131_ AFVFL 136_ LVFGC 141_ LILSV 146_ FSTIP 151_ EHTKL 156_ ASSCL 161_ LILEF 166_ VMIVV 171_ FGLEF 176_ IIRIW 181_ SAGCC 186_ CRYRG 191_ WQGRL 196_ RFARK 201_ PFCVI 206_ DTIVL 211_ IASIA 216_ VVSAK 221_ TQGNI 226_ FATSA 231_ LRSLR 236_ FLQIL 241_ RMVRM 246_ DRRGG 251_ TWKLL 256_ GSVVY 261_ AHSKE 266_ LITAW 271_ YIGFL 276_ VLIFS 281_ SFLVY 286_ LVEKD 291_ ANKEF 296_ STYAD 301_ ALWWG 306_ TITLT 311_ TIGYG 316_ DKTPL 321_ TWLGR 326_ LLSAG 331_ FALLG 336_ ISFFA 341_ LPAGI 346_ LGSGF 351_ ALKVQ 356_ EQHRQ 361_ KHFEK 366_ RRNPA 371_ ANLIQ 376_ CVWRS 381_ YAADE 386_ KSVSI 391_ ATWKP 396_ HLKAL 401_ HTCSP 406_ TKKEQ 411_ GEASS 416_ SQKLS 421_ FKERV 426_ RMASP 431_ RGQSI 436_ KSRQA 441_ SVGDR 446_ RSPST 451_ DITAE 456_ GSPTK 461_ VQKSW 466_ SFNDR 471_ TRFRP 476_ SLRLK 481_ SSQPK 486_ PVIDA 491_ DTALG 496_ TDDVY 501_ DEKGC 506_ QCDVS 511_ VEDLT 516_ PPLKT 521_ VIRAI 526_ RIMKF 531_ HVAKR 536_ KFKET 541_ LRPYD 546_ VKDVI 551_ EQYSA 556_ GHLDM 561_ LCRIK 566_ SLQTR 571_ VDQIL 576_ GKGQI 581_ TSDKK 586_ SREKI 591_ TAEHE 596_ TTDDL 601_ SMLGR 606_ VVKVE 611_ KQVQS 616_ IESKL 621_ DCLLD 626_ IYQQV 631_ LRKGS 636_ ASALA 641_ LASFQ 646_ IPPFE 651_ CEQTS 656_ DYQSP 661_ VDSKD 666_ LSGSA 671_ QNSGC 676_ LSRST 681_ SANIS 686_ RGLQF 691_ ILTPN 696_ EFSAQ 701_ TFYAL 706_ SPTMH 711_ SQATQ 716_ VPISQ 721_ SDGSA 726_ VAATN 731_ TIANQ 736_ INTAP 741_ KPAAP 746_ TTLQI 751_ PPPLP 756_ AIKHL 761_ PRPET 766_ LHPNP 771_ AGLQE 776_ SISDV 781_ TTCLV 786_ ASKEN 791_ VQVAQ 796_ SNLTK 801_ DRSMR 806_ KSFDM 811_ GGETL 816_ LSVCP 821_ MVPKD 826_ LGKSL 831_ SVQNL 836_ IRSTE 841_ ELNIQ 846_ LSGSE 851_ SSGSR 856_ GSQDF 861_ YPKWR 866_ ESKLF 871_ ITDEE 876_ VGPEE 881_ TETDT 886_ FDAAP 891_ QPARE 896_ AAFAS 901_ DSLRT 906_ GRSRS 911_ SQSIC 916_ KAGES 921_ TDALS 926_LPHVK
1: Pore-forming subunit of the voltage-gated potassium (Kv) channel broadly expressed in brain and involved in the regulation of neuronal excitability (PubMed:10787416, PubMed:10816588, PubMed:11159685, PubMed:28669405). Associates with KCNQ3/Kv7.3 pore-forming subunit to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons (PubMed:10816588, PubMed:11159685). Contributes, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current (PubMed:10816588). Also forms a functional channel with KCNQ1/Kv7.1 subunit that may contribute to vasoconstriction and hypertension (PubMed:24855057). Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+) (PubMed:10816588). Similar to the native M-channel, KCNQ3-KCNQ5 potassium channel is suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10816588)