Toll-like receptor 9 (CD antigen CD289)
1_MGFCR 6_ SALHP 11_ LSLLV 16_ QAIML 21_ AMTLA 26_ LGTLP 31_ AFLPC 36_ ELQPH 41_ GLVNC 46_ NWLFL 51_ KSVPH 56_ FSMAA 61_ PRGNV 66_ TSLSL 71_ SSNRI 76_ HHLHD 81_ SDFAH 86_ LPSLR 91_ HLNLK 96_ WNCPP 101_ VGLSP 106_ MHFPC 111_ HMTIE 116_ PSTFL 121_ AVPTL 126_ EELNL 131_ SYNNI 136_ MTVPA 141_ LPKSL 146_ ISLSL 151_ SHTNI 156_ LMLDS 161_ ASLAG 166_ LHALR 171_ FLFMD 176_ GNCYY 181_ KNPCR 186_ QALEV 191_ APGAL 196_ LGLGN 201_ LTHLS 206_ LKYNN 211_ LTVVP 216_ RNLPS 221_ SLEYL 226_ LLSYN 231_ RIVKL 236_ APEDL 241_ ANLTA 246_ LRVLD 251_ VGGNC 256_ RRCDH 261_ APNPC 266_ MECPR 271_ HFPQL 276_ HPDTF 281_ SHLSR 286_ LEGLV 291_ LKDSS 296_ LSWLN 301_ ASWFR 306_ GLGNL 311_ RVLDL 316_ SENFL 321_ YKCIT 326_ KTKAF 331_ QGLTQ 336_ LRKLN 341_ LSFNY 346_ QKRVS 351_ FAHLS 356_ LAPSF 361_ GSLVA 366_ LKELD 371_ MHGIF 376_ FRSLD 381_ ETTLR 386_ PLARL 391_ PMLQT 396_ LRLQM 401_ NFINQ 406_ AQLGI 411_ FRAFP 416_ GLRYV 421_ DLSDN 426_ RISGA 431_ SELTA 436_ TMGEA 441_ DGGEK 446_ VWLQP 451_ GDLAP 456_ APVDT 461_ PSSED 466_ FRPNC 471_ STLNF 476_ TLDLS 481_ RNNLV 486_ TVQPE 491_ MFAQL 496_ SHLQC 501_ LRLSH 506_ NCISQ 511_ AVNGS 516_ QFLPL 521_ TGLQV 526_ LDLSH 531_ NKLDL 536_ YHEHS 541_ FTELP 546_ RLEAL 551_ DLSYN 556_ SQPFG 561_ MQGVG 566_ HNFSF 571_ VAHLR 576_ TLRHL 581_ SLAHN 586_ NIHSQ 591_ VSQQL 596_ CSTSL 601_ RALDF 606_ SGNAL 611_ GHMWA 616_ EGDLY 621_ LHFFQ 626_ GLSGL 631_ IWLDL 636_ SQNRL 641_ HTLLP 646_ QTLRN 651_ LPKSL 656_ QVLRL 661_ RDNYL 666_ AFFKW 671_ WSLHF 676_ LPKLE 681_ VLDLA 686_ GNQLK 691_ ALTNG 696_ SLPAG 701_ TRLRR 706_ LDVSC 711_ NSISF 716_ VAPGF 721_ FSKAK 726_ ELREL 731_ NLSAN 736_ ALKTV 741_ DHSWF 746_ GPLAS 751_ ALQIL 756_ DVSAN 761_ PLHCA 766_ CGAAF 771_ MDFLL 776_ EVQAA 781_ VPGLP 786_ SRVKC 791_ GSPGQ 796_ LQGLS 801_ IFAQD 806_ LRLCL 811_ DEALS 816_ WDCFA 821_ LSLLA 826_ VALGL 831_ GVPML 836_ HHLCG 841_ WDLWY 846_ CFHLC 851_ LAWLP 856_ WRGRQ 861_ SGRDE 866_ DALPY 871_ DAFVV 876_ FDKTQ 881_ SAVAD 886_ WVYNE 891_ LRGQL 896_ EECRG 901_ RWALR 906_ LCLEE 911_ RDWLP 916_ GKTLF 921_ ENLWA 926_ SVYGS 931_ RKTLF 936_ VLAHT 941_ DRVSG 946_ LLRAS 951_ FLLAQ 956_ QRLLE 961_ DRKDV 966_ VVLVI 971_ LSPDG 976_ RRSRY 981_ VRLRQ 986_ RLCRQ 991_ SVLLW 996_ PHQPS 1001_ GQRSF 1006_ WAQLG 1011_ MALTR 1016_ DNHHF 1021_ YNRNF 1026_CQGPT
1: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:14716310). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366)