Toll-like receptor 8 (CD antigen CD288)
1_MENMF 6_ LQSSM 11_ LTCIF 16_ LLISG 21_ SCELC 26_ AEENF 31_ SRSYP 36_ CDEKK 41_ QNDSV 46_ IAECS 51_ NRRLQ 56_ EVPQT 61_ VGKYV 66_ TELDL 71_ SDNFI 76_ THITN 81_ ESFQG 86_ LQNLT 91_ KINLN 96_ HNPNV 101_ QHQNG 106_ NPGIQ 111_ SNGLN 116_ ITDGA 121_ FLNLK 126_ NLREL 131_ LLEDN 136_ QLPQI 141_ PSGLP 146_ ESLTE 151_ LSLIQ 156_ NNIYN 161_ ITKEG 166_ ISRLI 171_ NLKNL 176_ YLAWN 181_ CYFNK 186_ VCEKT 191_ NIEDG 196_ VFETL 201_ TNLEL 206_ LSLSF 211_ NSLSH 216_ VPPKL 221_ PSSLR 226_ KLFLS 231_ NTQIK 236_ YISEE 241_ DFKGL 246_ INLTL 251_ LDLSG 256_ NCPRC 261_ FNAPF 266_ PCVPC 271_ DGGAS 276_ INIDR 281_ FAFQN 286_ LTQLR 291_ YLNLS 296_ STSLR 301_ KINAA 306_ WFKNM 311_ PHLKV 316_ LDLEF 321_ NYLVG 326_ EIASG 331_ AFLTM 336_ LPRLE 341_ ILDLS 346_ FNYIK 351_ GSYPQ 356_ HINIS 361_ RNFSK 366_ LLSLR 371_ ALHLR 376_ GYVFQ 381_ ELRED 386_ DFQPL 391_ MQLPN 396_ LSTIN 401_ LGINF 406_ IKQID 411_ FKLFQ 416_ NFSNL 421_ EIIYL 426_ SENRI 431_ SPLVK 436_ DTRQS 441_ YANSS 446_ SFQRH 451_ IRKRR 456_ STDFE 461_ FDPHS 466_ NFYHF 471_ TRPLI 476_ KPQCA 481_ AYGKA 486_ LDLSL 491_ NSIFF 496_ IGPNQ 501_ FENLP 506_ DIACL 511_ NLSAN 516_ SNAQV 521_ LSGTE 526_ FSAIP 531_ HVKYL 536_ DLTNN 541_ RLDFD 546_ NASAL 551_ TELSD 556_ LEVLD 561_ LSYNS 566_ HYFRI 571_ AGVTH 576_ HLEFI 581_ QNFTN 586_ LKVLN 591_ LSHNN 596_ IYTLT 601_ DKYNL 606_ ESKSL 611_ VELVF 616_ SGNRL 621_ DILWN 626_ DDDNR 631_ YISIF 636_ KGLKN 641_ LTRLD 646_ LSLNR 651_ LKHIP 656_ NEAFL 661_ NLPAS 666_ LTELH 671_ INDNM 676_ LKFFN 681_ WTLLQ 686_ QFPRL 691_ ELLDL 696_ RGNKL 701_ LFLTD 706_ SLSDF 711_ TSSLR 716_ TLLLS 721_ HNRIS 726_ HLPSG 731_ FLSEV 736_ SSLKH 741_ LDLSS 746_ NLLKT 751_ INKSA 756_ LETKT 761_ TTKLS 766_ MLELH 771_ GNPFE 776_ CTCDI 781_ GDFRR 786_ WMDEH 791_ LNVKI 796_ PRLVD 801_ VICAS 806_ PGDQR 811_ GKSIV 816_ SLELT 821_ TCVSD 826_ VTAVI 831_ LFFFT 836_ FFITT 841_ MVMLA 846_ ALAHH 851_ LFYWD 856_ VWFIY 861_ NVCLA 866_ KVKGY 871_ RSLST 876_ SQTFY 881_ DAYIS 886_ YDTKD 891_ ASVTD 896_ WVINE 901_ LRYHL 906_ EESRD 911_ KNVLL 916_ CLEER 921_ DWDPG 926_ LAIID 931_ NLMQS 936_ INQSK 941_ KTVFV 946_ LTKKY 951_ AKSWN 956_ FKTAF 961_ YLALQ 966_ RLMDE 971_ NMDVI 976_ IFILL 981_ EPVLQ 986_ HSQYL 991_ RLRQR 996_ ICKSS 1001_ ILQWP 1006_ DNPKA 1011_ EGLFW 1016_ QTLRN 1021_ VVLTE 1026_ NDSRY 1031_ NNMYV 1036_DSIKQ
1: Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:25297876, PubMed:32433612). Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2 (PubMed:31778653). Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses (PubMed:33718825). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:23520111, PubMed:25599397, PubMed:26929371, PubMed:33718825). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:16737960, PubMed:17932028, PubMed:29155428)