Platelet-derived growth factor C (PDGF-C) (Fallotein) (Spinal cord-derived growth factor) (SCDGF) (VEGF-E) [Cleaved into: Platelet-derived growth factor C, latent form (PDGFC latent form); Platelet-derived growth factor C, receptor-binding form (PDGFC receptor-binding form)]
1_MSLFG 6_ LLLLT 11_ SALAG 16_ QRQGT 21_ QAESN 26_ LSSKF 31_ QFSSN 36_ KEQNG 41_ VQDPQ 46_ HERII 51_ TVSTN 56_ GSIHS 61_ PRFPH 66_ TYPRN 71_ TVLVW 76_ RLVAV 81_ EENVW 86_ IQLTF 91_ DERFG 96_ LEDPE 101_ DDICK 106_ YDFVE 111_ VEEPS 116_ DGTIL 121_ GRWCG 126_ SGTVP 131_ GKQIS 136_ KGNQI 141_ RIRFV 146_ SDEYF 151_ PSEPG 156_ FCIHY 161_ NIVMP 166_ QFTEA 171_ VSPSV 176_ LPPSA 181_ LPLDL 186_ LNNAI 191_ TAFST 196_ LEDLI 201_ RYLEP 206_ ERWQL 211_ DLEDL 216_ YRPTW 221_ QLLGK 226_ AFVFG 231_ RKSRV 236_ VDLNL 241_ LTEEV 246_ RLYSC 251_ TPRNF 256_ SVSIR 261_ EELKR 266_ TDTIF 271_ WPGCL 276_ LVKRC 281_ GGNCA 286_ CCLHN 291_ CNECQ 296_ CVPSK 301_ VTKKY 306_ HEVLQ 311_ LRPKT 316_ GVRGL 321_ HKSLT 326_ DVALE 331_ HHEEC 336_DCVCR
1: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function