Sialin (H(+)/nitrate cotransporter) (H(+)/sialic acid cotransporter) (AST) (Membrane glycoprotein HP59) (Solute carrier family 17 member 5) (Vesicular H(+)/Aspartate-glutamate cotransporter)
1_MRSPV 6_ RDLAR 11_ NDGEE 16_ STDRT 21_ PLLPG 26_ APRAE 31_ AAPVC 36_ CSARY 41_ NLAIL 46_ AFFGF 51_ FIVYA 56_ LRVNL 61_ SVALV 66_ DMVDS 71_ NTTLE 76_ DNRTS 81_ KACPE 86_ HSAPI 91_ KVHHN 96_ QTGKK 101_ YQWDA 106_ ETQGW 111_ ILGSF 116_ FYGYI 121_ ITQIP 126_ GGYVA 131_ SKIGG 136_ KMLLG 141_ FGILG 146_ TAVLT 151_ LFTPI 156_ AADLG 161_ VGPLI 166_ VLRAL 171_ EGLGE 176_ GVTFP 181_ AMHAM 186_ WSSWA 191_ PPLER 196_ SKLLS 201_ ISYAG 206_ AQLGT 211_ VISLP 216_ LSGII 221_ CYYMN 226_ WTYVF 231_ YFFGT 236_ IGIFW 241_ FLLWI 246_ WLVSD 251_ TPQKH 256_ KRISH 261_ YEKEY 266_ ILSSL 271_ RNQLS 276_ SQKSV 281_ PWVPI 286_ LKSLP 291_ LWAIV 296_ VAHFS 301_ YNWTF 306_ YTLLT 311_ LLPTY 316_ MKEIL 321_ RFNVQ 326_ ENGFL 331_ SSLPY 336_ LGSWL 341_ CMILS 346_ GQAAD 351_ NLRAK 356_ WNFST 361_ LCVRR 366_ IFSLI 371_ GMIGP 376_ AVFLV 381_ AAGFI 386_ GCDYS 391_ LAVAF 396_ LTIST 401_ TLGGF 406_ CSSGF 411_ SINHL 416_ DIAPS 421_ YAGIL 426_ LGITN 431_ TFATI 436_ PGMVG 441_ PVIAK 446_ SLTPD 451_ NTVGE 456_ WQTVF 461_ YIAAA 466_ INVFG 471_ AIFFT 476_ LFAKG 481_ EVQNW 486_ALNDH
1: Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport (PubMed:15510212, PubMed:21781115, PubMed:22778404, PubMed:23889254). Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system (By similarity) (PubMed:15510212, PubMed:21781115, PubMed:22778404, PubMed:23889254). Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva (PubMed:22778404). Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release (By similarity) (PubMed:21781115, PubMed:22778404, PubMed:23889254)
2: Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties