Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1)
1_MDRRS 6_ MGETE 11_ SGDAF 16_ LDLKK 21_ PPASK 26_ CPHRY 31_ TKEEL 36_ LDIKE 41_ LPHSK 46_ QRPSC 51_ LSEKY 56_ DSDGV 61_ WDPEK 66_ WHASL 71_ YPASG 76_ RSSPV 81_ ESLKK 86_ ELDTD 91_ RPSLV 96_ RRIVD 101_ PRERV 106_ KEDDL 111_ DVVLS 116_ PQRRS 121_ FGGGC 126_ HVTAA 131_ VSSRR 136_ SGSPL 141_ EKDSD 146_ GLRLL 151_ GGRRI 156_ GSGRI 161_ ISART 166_ FEKDH 171_ RLSDK 176_ DLRDL 181_ RDRDR 186_ ERDFK 191_ DKRFR 196_ REFGD 201_ SKRVF 206_ GERRR 211_ NDSYT 216_ EEEPE 221_ WFSAG 226_ PTSQS 231_ ETIEL 236_ TGFDD 241_ KILEE 246_ DHKGR 251_ KRTRR 256_ RTASV 261_ KEGIV 266_ ECNGG 271_ VAEED 276_ EVEVI 281_ LAQEP 286_ AADQE 291_ VPRDA 296_ VLPEQ 301_ SPGDF 306_ DFNEF 311_ FNLDK 316_ VPCLA 321_ SMIED 326_ VLGEG 331_ SVSAS 336_ RFSRW 341_ FSNPS 346_ RSGSR 351_ SSSLG 356_ STPHE 361_ ELERL 366_ AGLEQ 371_ AILSP 376_ GQNSG 381_ NYFAP 386_ IPLED 391_ HAENK 396_ VDILE 401_ MLQKA 406_ KVDLK 411_ PLLSS 416_ LSANK 421_ EKLKE 426_ SSHSG 431_ VVLSV 436_ EEVEA 441_ GLKGL 446_ KVDQQ 451_ VKNST 456_ PFMAE 461_ HLEET 466_ LSAVT 471_ NNRQL 476_ KKDGD 481_ MTAFN 486_ KLVST 491_ MKASG 496_ TLPSQ 501_ PKVSR 506_ NLESH 511_ LMSPA 516_ EIPGQ 521_ PVPKN 526_ ILQEL 531_ LGQPV 536_ QRPAS 541_ SNLLS 546_ GLMGS 551_ LEPTT 556_ SLLGQ 561_ RAPSP 566_ PLSQV 571_ FQTRA 576_ ASADY 581_ LRPRI 586_ PSPIG 591_ FTPGP 596_ QQLLG 601_ DPFQG 606_ MRKPM 611_ SPITA 616_ QMSQL 621_ ELQQA 626_ ALEGL 631_ ALPHD 636_ LAVQA 641_ ANFYQ 646_ PGFGK 651_ PQVDR 656_ TRDGF 661_ RNRQQ 666_ RVTKS 671_ PAPVH 676_ RGNSS 681_ SPAPA 686_ ASITS 691_ MLSPS 696_ FTPTS 701_ VIRKM 706_ YESKE 711_ KSKEE 716_ PASGK 721_ AALGD 726_ SKEDT 731_ QKASE 736_ ENLLS 741_ SSSVP 746_ SADRD 751_ SSPTT 756_ NSKLS 761_ ALQRS 766_ SCSTP 771_ LSQAN 776_ RYTKE 781_ QDYRP 786_ KATGR 791_ KTPTL 796_ ASPVP 801_ TTPFL 806_ RPVHQ 811_ VPLVP 816_ HVPMV 821_ RPAHQ 826_ LHPGL 831_ VQRML 836_ AQGVH 841_ PQHLP 846_ SLLQT 851_ GVLPP 856_ GMDLS 861_ HLQGI 866_ SGPIL 871_ GQPFY 876_ PLPAA 881_ SHPLL 886_ NPRPG 891_ TPLHL 896_ AMVQQ 901_ QLQRS 906_ VLHPP 911_ GSGSH 916_ AAAVS 921_ VQTTP 926_ QNVPS 931_ RSGLP 936_ HMHSQ 941_ LEHRP 946_ SQRSS 951_ SPVGL 956_ AKWFG 961_ SDVLQ 966_ QPLPS 971_ MPAKV 976_ISVDE
1: EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671)