Carbohydrate sulfotransferase 12 (EC 2.8.2.5) (Chondroitin 4-O-sulfotransferase 2) (Chondroitin 4-sulfotransferase 2) (C4ST-2) (C4ST2) (Sulfotransferase Hlo)
1_MTKAR 6_ LFRLW 11_ LVLGS 16_ VFMIL 21_ LIIVY 26_ WDSAG 31_ AAHFY 36_ LHTSF 41_ SRPHT 46_ GPPLP 51_ TPGPD 56_ RDREL 61_ TADSD 66_ VDEFL 71_ DKFLS 76_ AGVKQ 81_ SDLPR 86_ KETEQ 91_ PPAPG 96_ SMEES 101_ VRGYD 106_ WSPRD 111_ ARRSP 116_ DQGRQ 121_ QAERR 126_ SVLRG 131_ FCANS 136_ SLAFP 141_ TKERA 146_ FDDIP 151_ NSELS 156_ HLIVD 161_ DRHGA 166_ IYCYV 171_ PKVAC 176_ TNWKR 181_ VMIVL 186_ SGSLL 191_ HRGAP 196_ YRDPL 201_ RIPRE 206_ HVHNA 211_ SAHLT 216_ FNKFW 221_ RRYGK 226_ LSRHL 231_ MKVKL 236_ KKYTK 241_ FLFVR 246_ DPFVR 251_ LISAF 256_ RSKFE 261_ LENEE 266_ FYRKF 271_ AVPML 276_ RLYAN 281_ HTSLP 286_ ASARE 291_ AFRAG 296_ LKVSF 301_ ANFIQ 306_ YLLDP 311_ HTEKL 316_ APFNE 321_ HWRQV 326_ YRLCH 331_ PCQID 336_ YDFVG 341_ KLETL 346_ DEDAA 351_ QLLQL 356_ LQVDR 361_ QLRFP 366_ PSYRN 371_ RTASS 376_ WEEDW 381_ FAKIP 386_ LAWRQ 391_ QLYKL 396_ YEADF 401_ VLFGY 406_PKPEN
1: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor