PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein)
1_MFADL 6_ DYDIE 11_ EDKLG 16_ IPTVP 21_ GKVTL 26_ QKDAQ 31_ NLIGI 36_ SIGGG 41_ AQYCP 46_ CLYIV 51_ QVFDN 56_ TPAAL 61_ DGTVA 66_ AGDEI 71_ TGVNG 76_ RSIKG 81_ KTKVE 86_ VAKMI 91_ QEVKG 96_ EVTIH 101_ YNKLQ 106_ ADPKQ 111_ GMSLD 116_ IVLKK 121_ VKHRL 126_ VENMS 131_ SGTAD 136_ ALGLS 141_ RAILC 146_ NDGLV 151_ KRLEE 156_ LERTA 161_ ELYKG 166_ MTEHT 171_ KNLLR 176_ AFYEL 181_ SQTHR 186_ AFGDV 191_ FSVIG 196_ VREPQ 201_ PAASE 206_ AFVKF 211_ ADAHR 216_ SIEKF 221_ GIRLL 226_ KTIKP 231_ MLTDL 236_ NTYLN 241_ KAIPD 246_ TRLTI 251_ KKYLD 256_ VKFEY 261_ LSYCL 266_ KVKEM 271_ DDEEY 276_ SCIAL 281_ GEPLY 286_ RVSTG 291_ NYEYR 296_ LILRC 301_ RQEAR 306_ ARFSQ 311_ MRKDV 316_ LEKME 321_ LLDQK 326_ HVQDI 331_ VFQLQ 336_ RLVST 341_ MSKYY 346_ NDCYA 351_ VLRDA 356_ DVFPI 361_ EVDLA 366_ HTTLA 371_ YGLNQ 376_ EEFTD 381_ GEEEE 386_ EEEDT 391_ AAGEP 396_ SRDTR 401_ GAAGP 406_LDKGG
1: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function