Dual oxidase 2 (EC 1.11.1.-) (EC 1.6.3.1) (Large NOX 2) (Long NOX 2) (NADH/NADPH thyroid oxidase p138-tox) (NADPH oxidase/peroxidase DUOX2) (NADPH thyroid oxidase 2) (Thyroid oxidase 2) (p138 thyroid oxidase)
1_MLRAR 6_ PEALM 11_ LLGAL 16_ LTGSL 21_ GPSGN 26_ QDALS 31_ LPWEV 36_ QRYDG 41_ WFNNL 46_ RHHER 51_ GAVGC 56_ RLQRR 61_ VPANY 66_ ADGVY 71_ QALEE 76_ PQLPN 81_ PRRLS 86_ NAATR 91_ GIAGL 96_ PSLHN 101_ RTVLG 106_ VFFGY 111_ HVLSD 116_ VVSVE 121_ TPGCP 126_ AEFLN 131_ IRIPP 136_ GDPVF 141_ DPDQR 146_ GDVVL 151_ PFQRS 156_ RWDPE 161_ TGRSP 166_ SNPRD 171_ LANQV 176_ TGWLD 181_ GSAIY 186_ GSSHS 191_ WSDAL 196_ RSFSG 201_ GQLAS 206_ GPDPA 211_ FPRDS 216_ QNPLL 221_ MWAAP 226_ DPATG 231_ QNGPR 236_ GLYAF 241_ GAERG 246_ NREPF 251_ LQALG 256_ LLWFR 261_ YHNLW 266_ AQRLA 271_ RQHPD 276_ WEDEE 281_ LFQHA 286_ RKRVI 291_ ATYQN 296_ IAVYE 301_ WLPSF 306_ LQKTL 311_ PEYTG 316_ YRPFL 321_ DPSIS 326_ PEFVV 331_ ASEQF 336_ FSTMV 341_ PPGVY 346_ MRNAS 351_ CHFRK 356_ VLNKG 361_ FQSSQ 366_ ALRVC 371_ NNYWI 376_ RENPN 381_ LNSTQ 386_ EVNEL 391_ LLGMA 396_ SQISE 401_ LEDNI 406_ VVEDL 411_ RDYWP 416_ GPGKF 421_ SRTDY 426_ VASSI 431_ QRGRD 436_ MGLPS 441_ YSQAL 446_ LAFGL 451_ DIPRN 456_ WSDLN 461_ PNVDP 466_ QVLEA 471_ TAALY 476_ NQDLS 481_ QLELL 486_ LGGLL 491_ ESHGD 496_ PGPLF 501_ SAIVL 506_ DQFVR 511_ LRDGD 516_ RYWFE 521_ NTRNG 526_ LFSKK 531_ EIEDI 536_ RNTTL 541_ RDVLV 546_ AVINI 551_ DPSAL 556_ QPNVF 561_ VWHKG 566_ APCPQ 571_ PKQLT 576_ TDGLP 581_ QCAPL 586_ TVLDF 591_ FEGSS 596_ PGFAI 601_ TIIAL 606_ CCLPL 611_ VSLLL 616_ SGVVA 621_ YFRGR 626_ EHKKL 631_ QKKLK 636_ ESVKK 641_ EAAKD 646_ GVPAM 651_ EWPGP 656_ KERSS 661_ PIIIQ 666_ LLSDR 671_ CLQVL 676_ NRHLT 681_ VLRVV 686_ QLQPL 691_ QQVNL 696_ ILSNN 701_ RGCRT 706_ LLLKI 711_ PKEYD 716_ LVLLF 721_ SSEEE 726_ RGAFV 731_ QQLWD 736_ FCVRW 741_ ALGLH 746_ VAEMS 751_ EKELF 756_ RKAVT 761_ KQQRE 766_ RILEI 771_ FFRHL 776_ FAQVL 781_ DINQA 786_ DAGTL 791_ PLDSS 796_ QKVRE 801_ ALTCE 806_ LSRAE 811_ FAESL 816_ GLKPQ 821_ DMFVE 826_ SMFSL 831_ ADKDG 836_ NGYLS 841_ FREFL 846_ DILVV 851_ FMKGS 856_ PEDKS 861_ RLMFT 866_ MYDLD 871_ ENGFL 876_ SKDEF 881_ FTMMR 886_ SFIEI 891_ SNNCL 896_ SKAQL 901_ AEVVE 906_ SMFRE 911_ SGFQD 916_ KEELT 921_ WEDFH 926_ FMLRD 931_ HDSEL 936_ RFTQL 941_ CVKGG 946_ GGGGN 951_ GIRDI 956_ FKQNI 961_ SCRVS 966_ FITRT 971_ PGERS 976_ HPQGL 981_ GPPAP 986_ EAPEL 991_ GGPGL 996_ KKRFG 1001_ KKAAV 1006_ PTPRL 1011_ YTEAL 1016_ QEKMQ 1021_ RGFLA 1026_ QKLQQ 1031_ YKRFV 1036_ ENYRR 1041_ HIVCV 1046_ AIFSA 1051_ ICVGV 1056_ FADRA 1061_ YYYGF 1066_ ASPPS 1071_ DIAQT 1076_ TLVGI 1081_ ILSRG 1086_ TAASV 1091_ SFMFS 1096_ YILLT 1101_ MCRNL 1106_ ITFLR 1111_ ETFLN 1116_ RYVPF 1121_ DAAVD 1126_ FHRWI 1131_ AMAAV 1136_ VLAIL 1141_ HSAGH 1146_ AVNVY 1151_ IFSVS 1156_ PLSLL 1161_ ACIFP 1166_ NVFVN 1171_ DGSKL 1176_ PQKFY 1181_ WWFFQ 1186_ TVPGM 1191_ TGVLL 1196_ LLVLA 1201_ IMYVF 1206_ ASHHF 1211_ RRRSF 1216_ RGFWL 1221_ THHLY 1226_ ILLYA 1231_ LLIIH 1236_ GSYAL 1241_ IQLPT 1246_ FHIYF 1251_ LVPAI 1256_ IYGGD 1261_ KLVSL 1266_ SRKKV 1271_ EISVV 1276_ KAELL 1281_ PSGVT 1286_ YLQFQ 1291_ RPQGF 1296_ EYKSG 1301_ QWVRI 1306_ ACLAL 1311_ GTTEY 1316_ HPFTL 1321_ TSAPH 1326_ EDTLS 1331_ LHIRA 1336_ VGPWT 1341_ TRLRE 1346_ IYSSP 1351_ KGNGC 1356_ AGYPK 1361_ LYLDG 1366_ PFGEG 1371_ HQEWH 1376_ KFEVS 1381_ VLVGG 1386_ GIGVT 1391_ PFASI 1396_ LKDLV 1401_ FKSSL 1406_ GSQML 1411_ CKKIY 1416_ FIWVT 1421_ RTQRQ 1426_ FEWLA 1431_ DIIQE 1436_ VEEND 1441_ HQDLV 1446_ SVHIY 1451_ VTQLA 1456_ EKFDL 1461_ RTTML 1466_ YICER 1471_ HFQKV 1476_ LNRSL 1481_ FTGLR 1486_ SITHF 1491_ GRPPF 1496_ EPFFN 1501_ SLQEV 1506_ HPQVR 1511_ KIGVF 1516_ SCGPP 1521_ GMTKN 1526_ VEKAC 1531_ QLVNR 1536_ QDRAH 1541_FMHHY
1: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain