N-lysine methyltransferase SMYD2 (EC 2.1.1.-) (HSKM-B) (Histone methyltransferase SMYD2) (EC 2.1.1.354) (Lysine N-methyltransferase 3C) (SET and MYND domain-containing protein 2)
1_MRAEG 6_ LGGLE 11_ RFCSP 16_ GKGRG 21_ LRALQ 26_ PFQVG 31_ DLLFS 36_ CPAYA 41_ YVLTV 46_ NERGN 51_ HCEYC 56_ FTRKE 61_ GLSKC 66_ GRCKQ 71_ AFYCN 76_ VECQK 81_ EDWPM 86_ HKLEC 91_ SPMVV 96_ FGENW 101_ NPSET 106_ VRLTA 111_ RILAK 116_ QKIHP 121_ ERTPS 126_ EKLLA 131_ VKEFE 136_ SHLDK 141_ LDNEK 146_ KDLIQ 151_ SDIAA 156_ LHHFY 161_ SKHLG 166_ FPDND 171_ SLVVL 176_ FAQVN 181_ CNGFT 186_ IEDEE 191_ LSHLG 196_ SAIFP 201_ DVALM 206_ NHSCC 211_ PNVIV 216_ TYKGT 221_ LAEVR 226_ AVQEI 231_ KPGEE 236_ VFTSY 241_ IDLLY 246_ PTEDR 251_ NDRLR 256_ DSYFF 261_ TCECQ 266_ ECTTK 271_ DKDKA 276_ KVEIR 281_ KLSDP 286_ PKAEA 291_ IRDMV 296_ RYARN 301_ VIEEF 306_ RRAKH 311_ YKSPS 316_ ELLEI 321_ CELSQ 326_ EKMSS 331_ VFEDS 336_ NVYML 341_ HMMYQ 346_ AMGVC 351_ LYMQD 356_ WEGAL 361_ QYGQK 366_ IIKPY 371_ SKHYP 376_ LYSLN 381_ VASMW 386_ LKLGR 391_ LYMGL 396_ EHKAA 401_ GEKAL 406_ KKAIA 411_ IMEVA 416_ HGKDH 421_ PYISE 426_IKQEI
1: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'