Disrupted in schizophrenia 1 protein
1_MPGGG 6_ PQGAP 11_ AAAGG 16_ GGVSH 21_ RAGSR 26_ DCLPP 31_ AACFR 36_ RRRLA 41_ RRPGY 46_ MRSST 51_ GPGIG 56_ FLSPA 61_ VGTLF 66_ RFPGG 71_ VSGEE 76_ SHHSE 81_ SRARQ 86_ CGLDS 91_ RGLLV 96_ RSPVS 101_ KSAAA 106_ PTVTS 111_ VRGTS 116_ AHFGI 121_ QLRGG 126_ TRLPD 131_ RLSWP 136_ CGPGS 141_ AGWQQ 146_ EFAAM 151_ DSSET 156_ LDASW 161_ EAACS 166_ DGARR 171_ VRAAG 176_ SLPSA 181_ ELSSN 186_ SCSPG 191_ CGPEV 196_ PPTPP 201_ GSHSA 206_ FTSSF 211_ SFIRL 216_ SLGSA 221_ GERGE 226_ AEGCP 231_ PSREA 236_ ESHCQ 241_ SPQEM 246_ GAKAA 251_ SLDGP 256_ HEDPR 261_ CLSRP 266_ FSLLA 271_ TRVSA 276_ DLAQA 281_ ARNSS 286_ RPERD 291_ MHSLP 296_ DMDPG 301_ SSSSL 306_ DPSLA 311_ GCGGD 316_ GSSGS 321_ GDAHS 326_ WDTLL 331_ RKWEP 336_ VLRDC 341_ LLRNR 346_ RQMEV 351_ ISLRL 356_ KLQKL 361_ QEDAV 366_ ENDDY 371_ DKAET 376_ LQQRL 381_ EDLEQ 386_ EKISL 391_ HFQLP 396_ SRQPA 401_ LSSFL 406_ GHLAA 411_ QVQAA 416_ LRRGA 421_ TQQAS 426_ GDDTH 431_ TPLRM 436_ EPRLL 441_ EPTAQ 446_ DSLHV 451_ SITRR 456_ DWLLQ 461_ EKQQL 466_ QKEIE 471_ ALQAR 476_ MFVLE 481_ AKDQQ 486_ LRREI 491_ EEQEQ 496_ QLQWQ 501_ GCDLT 506_ PLVGQ 511_ LSLGQ 516_ LQEVS 521_ KALQD 526_ TLASA 531_ GQIPF 536_ HAEPP 541_ ETIRS 546_ LQERI 551_ KSLNL 556_ SLKEI 561_ TTKVC 566_ MSEKF 571_ CSTLR 576_ KKVND 581_ IETQL 586_ PALLE 591_ AKMHA 596_ ISGNH 601_ FWTAK 606_ DLTEE 611_ IRSLT 616_ SEREG 621_ LEGLL 626_ SKLLV 631_ LSSRN 636_ VKKLG 641_ SVKED 646_ YNRLR 651_ REVEH 656_ QETAY 661_ ETSVK 666_ ENTMK 671_ YMETL 676_ KNKLC 681_ SCKCP 686_ LLGKV 691_ WEADL 696_ EACRL 701_ LIQSL 706_ QLQEA 711_ RGSLS 716_ VEDER 721_ QMDDL 726_ EGAAP 731_ PIPPR 736_ LHSED 741_ KRKTP 746_ LKVLE 751_ EWKTH 756_ LIPSL 761_ HCAGG 766_ EQKEE 771_ SYILS 776_ AELGE 781_ KCEDI 786_ GKKLL 791_ YLEDQ 796_ LHTAI 801_ HSHDE 806_ DLIQS 811_ LRREL 816_ QMVKE 821_ TLQAM 826_ ILQLQ 831_ PAKEA 836_ GEREA 841_ AASCM 846_TAGVH
1: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19303846, PubMed:19502360). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (PubMed:18955030)