Gene name: ABCB10

Uniprot entry:

Q9NRK6

Protein names:

ATP-binding cassette sub-family B member 10, mitochondrial (ABC-mitochondrial erythroid protein) (ABC-me protein) (ATP-binding cassette transporter 10) (ABC transporter 10 protein) (Mitochondrial ATP-binding cassette 2) (M-ABC2)

Protein sequence:

1_MRGPP 6_ AWPLR 11_ LLEPP 16_ SPAEP 21_ GRLLP 26_ VACVW 31_ AAASR 36_ VPGSL 41_ SPFTG 46_ LRPAR 51_ LWGAG 56_ PALLW 61_ GVGAA 66_ RRWRS 71_ GCRGG 76_ GPGAS 81_ RGVLG 86_ LARLL 91_ GLWAR 96_ GPGSC 101_ RCGAF 106_ AGPGA 111_ PRLPR 116_ ARFPG 121_ GPAAA 126_ AWAGD 131_ EAWRR 136_ GPAAP 141_ PGDKG 146_ RLRPA 151_ AAGLP 156_ EARKL 161_ LGLAY 166_ PERRR 171_ LAAAV 176_ GFLTM 181_ SSVIS 186_ MSAPF 191_ FLGKI 196_ IDVIY 201_ TNPTV 206_ DYSDN 211_ LTRLC 216_ LGLSA 221_ VFLCG 226_ AAANA 231_ IRVYL 236_ MQTSG 241_ QRIVN 246_ RLRTS 251_ LFSSI 256_ LRQEV 261_ AFFDK 266_ TRTGE 271_ LINRL 276_ SSDTA 281_ LLGRS 286_ VTENL 291_ SDGLR 296_ AGAQA 301_ SVGIS 306_ MMFFV 311_ SPNLA 316_ TFVLS 321_ VVPPV 326_ SIIAV 331_ IYGRY 336_ LRKLT 341_ KVTQD 346_ SLAQA 351_ TQLAE 356_ ERIGN 361_ VRTVR 366_ AFGKE 371_ MTEIE 376_ KYASK 381_ VDHVM 386_ QLARK 391_ EAFAR 396_ AGFFG 401_ ATGLS 406_ GNLIV 411_ LSVLY 416_ KGGLL 421_ MGSAH 426_ MTVGE 431_ LSSFL 436_ MYAFW 441_ VGISI 446_ GGLSS 451_ FYSEL 456_ MKGLG 461_ AGGRL 466_ WELLE 471_ REPKL 476_ PFNEG 481_ VILNE 486_ KSFQG 491_ ALEFK 496_ NVHFA 501_ YPARP 506_ EVPIF 511_ QDFSL 516_ SIPSG 521_ SVTAL 526_ VGPSG 531_ SGKST 536_ VLSLL 541_ LRLYD 546_ PASGT 551_ ISLDG 556_ HDIRQ 561_ LNPVW 566_ LRSKI 571_ GTVSQ 576_ EPILF 581_ SCSIA 586_ ENIAY 591_ GADDP 596_ SSVTA 601_ EEIQR 606_ VAEVA 611_ NAVAF 616_ IRNFP 621_ QGFNT 626_ VVGEK 631_ GVLLS 636_ GGQKQ 641_ RIAIA 646_ RALLK 651_ NPKIL 656_ LLDEA 661_ TSALD 666_ AENEY 671_ LVQEA 676_ LDRLM 681_ DGRTV 686_ LVIAH 691_ RLSTI 696_ KNANM 701_ VAVLD 706_ QGKIT 711_ EYGKH 716_ EELLS 721_ KPNGI 726_ YRKLM 731_NKQSF

Protein annotations

Protein functions:

1: ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress (PubMed:22085049, PubMed:28315685, PubMed:28808058, PubMed:34011630, PubMed:37041204). Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX) (PubMed:22085049, PubMed:28808058). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37 (By similarity). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (PubMed:28315685)