Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
1_MRPKT 6_ FPATT 11_ YSGNS 16_ RQRLQ 21_ EIREG 26_ LKQPS 31_ KSSVQ 36_ GLPAG 41_ PNSDT 46_ SLDAK 51_ VLGSK 56_ DATRQ 61_ QQQMR 66_ ATPKF 71_ GPYQK 76_ ALREI 81_ RYSLL 86_ PFANE 91_ SGTSA 96_ AAEVN 101_ RQMLQ 106_ ELVNA 111_ GCDQE 116_ MAGRA 121_ LKQTG 126_ SRSIE 131_ AALEY 136_ ISKMG 141_ YLDPR 146_ NEQIV 151_ RVIKQ 156_ TSPGK 161_ GLMPT 166_ PVTRR 171_ PSFEG 176_ TGDSF 181_ ASYHQ 186_ LSGTP 191_ YEGPS 196_ FGADG 201_ PTALE 206_ EMPRP 211_ YVDYL 216_ FPGVG 221_ PHGPG 226_ HQHQH 231_ PPKGY 236_ GASVE 241_ AAGAH 246_ FPLQG 251_ AHYGR 256_ PHLLV 261_ PGEPL 266_ GYGVQ 271_ RSPSF 276_ QSKTP 281_ PETGG 286_ YASLP 291_ TKGQG 296_ GPPGA 301_ GLAFP 306_ PPAAG 311_ LYVPH 316_ PHHKQ 321_ AGPAA 326_ HQLHV 331_ LGSRS 336_ QVFAS 341_ DSPPQ 346_ SLLTP 351_ SRNSL 356_ NVDLY 361_ ELGST 366_ SVQQW 371_ PAATL 376_ ARRDS 381_ LQKPG 386_ LEAPP 391_ RAHVA 396_ FRPDC 401_ PVPSR 406_ TNSFN 411_ SHQPR 416_ PGPPG 421_ KAEPS 426_ LPAPN 431_ TVTAV 436_ TAAHI 441_ LHPVK 446_ SVRVL 451_ RPEPQ 456_ TAVGP 461_ SHPAW 466_ VPAPA 471_ PAPAP 476_ APAPA 481_ AEGLD 486_ AKEEH 491_ ALALG 496_ GAGAF 501_ PLDVE 506_ YGGPD 511_ RRCPP 516_ PPYPK 521_ HLLLR 526_ SKSEQ 531_ YDLDS 536_ LCAGM 541_ EQSLR 546_ AGPNE 551_ PEGGD 556_ KSRKS 561_ AKGDK 566_ GGKDK 571_ KQIQT 576_ SPVPV 581_ RKNSR 586_ DEEKR 591_ ESRIK 596_ SYSPY 601_ AFKFF 606_ MEQHV 611_ ENVIK 616_ TYQQK 621_ VNRRL 626_ QLEQE 631_ MAKAG 636_ LCEAE 641_ QEQMR 646_ KILYQ 651_ KESNY 656_ NRLKR 661_ AKMDK 666_ SMFVK 671_ IKTLG 676_ IGAFG 681_ EVCLA 686_ CKVDT 691_ HALYA 696_ MKTLR 701_ KKDVL 706_ NRNQV 711_ AHVKA 716_ ERDIL 721_ AEADN 726_ EWVVK 731_ LYYSF 736_ QDKDS 741_ LYFVM 746_ DYIPG 751_ GDMMS 756_ LLIRM 761_ EVFPE 766_ HLARF 771_ YIAEL 776_ TLAIE 781_ SVHKM 786_ GFIHR 791_ DIKPD 796_ NILID 801_ LDGHI 806_ KLTDF 811_ GLCTG 816_ FRWTH 821_ NSKYY 826_ QKGSH 831_ VRQDS 836_ MEPSD 841_ LWDDV 846_ SNCRC 851_ GDRLK 856_ TLEQR 861_ ARKQH 866_ QRCLA 871_ HSLVG 876_ TPNYI 881_ APEVL 886_ LRKGY 891_ TQLCD 896_ WWSVG 901_ VILFE 906_ MLVGQ 911_ PPFLA 916_ PTPTE 921_ TQLKV 926_ INWEN 931_ TLHIP 936_ AQVKL 941_ SPEAR 946_ DLITK 951_ LCCSA 956_ DHRLG 961_ RNGAD 966_ DLKAH 971_ PFFSA 976_ IDFSS 981_ DIRKQ 986_ PAPYV 991_ PTISH 996_ PMDTS 1001_ NFDPV 1006_ DEESP 1011_ WNDAS 1016_ EGSTK 1021_ AWDTL 1026_ TSPNN 1031_ KHPEH 1036_ AFYEF 1041_ TFRRF 1046_ FDDNG 1051_ YPFRC 1056_ PKPSG 1061_ AEASQ 1066_ AESSD 1071_ LESSD 1076_ LVDQT 1081_EGCQP
1: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733). Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733). Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733). Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863). Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976). Negative regulator of the androgen receptor (PubMed:15131260). Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048). This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048). Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637)