rRNA N6-adenosine-methyltransferase METTL5 (EC 2.1.1.-) (Methyltransferase-like protein 5)
1_MKKVR 6_ LKELE 11_ SRLQQ 16_ VDGFE 21_ KPKLL 26_ LEQYP 31_ TRPHI 36_ AACML 41_ YTIHN 46_ TYDDI 51_ ENKVV 56_ ADLGC 61_ GCGVL 66_ SIGTA 71_ MLGAG 76_ LCVGF 81_ DIDED 86_ ALEIF 91_ NRNAE 96_ EFELT 101_ NIDMV 106_ QCDVC 111_ LLSNR 116_ MSKSF 121_ DTVIM 126_ NPPFG 131_ TKNNK 136_ GTDMA 141_ FLKTA 146_ LEMAR 151_ TAVYS 156_ LHKSS 161_ TREHV 166_ QKKAA 171_ EWKIK 176_ IDIIA 181_ ELRYD 186_ LPASY 191_ KFHKK 196_ KSVDI 201_EVDLI
1: Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:31328227, PubMed:32217665, PubMed:33357433, PubMed:33428944, PubMed:35033535). N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation (PubMed:33357433)