Oligosaccharyltransferase complex subunit OSTC (Hydrophobic protein HSF-28)
1_METLY 6_ RVPFL 11_ VLECP 16_ NLKLK 21_ KPPWL 26_ HMPSA 31_ MTVYA 36_ LVVVS 41_ YFLIT 46_ GGIIY 51_ DVIVE 56_ PPSVG 61_ SMTDE 66_ HGHQR 71_ PVAFL 76_ AYRVN 81_ GQYIM 86_ EGLAS 91_ SFLFT 96_ MGGLG 101_ FIILD 106_ RSNAP 111_ NIPKL 116_ NRFLL 121_ LFIGF 126_ VCVLL 131_ SFFMA 136_ RVFMR 141_MKLPG
1: Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:28860277, PubMed:31831667, PubMed:39509507). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) (PubMed:28860277, PubMed:31831667, PubMed:39509507). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex (PubMed:28860277). May be involved in N-glycosylation of APP (amyloid-beta precursor protein) (PubMed:21768116). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1 (PubMed:21768116)