Succinate dehydrogenase assembly factor 3, mitochondrial (SDH assembly factor 3) (SDHAF3)
1_MPGRH 6_ VSRVR 11_ ALYKR 16_ VLQLH 21_ RVLPP 26_ DLKSL 31_ GDQYV 36_ KDEFR 41_ RHKTV 46_ GSDEA 51_ QRFLQ 56_ EWEVY 61_ ATALL 66_ QQANE 71_ NRQNS 76_ TGKAC 81_ FGTFL 86_ PEEKL 91_ NDFRD 96_ EQIGQ 101_ LQELM 106_ QEATK 111_ PNRQF 116_SISES
1: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1