Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog)
1_MEKYH 6_ VLEMI 11_ GEGSF 16_ GRVYK 21_ GRRKY 26_ SAQVV 31_ ALKFI 36_ PKLGR 41_ SEKEL 46_ RNLQR 51_ EIEIM 56_ RGLRH 61_ PNIVH 66_ MLDSF 71_ ETDKE 76_ VVVVT 81_ DYAEG 86_ ELFQI 91_ LEDDG 96_ KLPED 101_ QVQAI 106_ AAQLV 111_ SALYY 116_ LHSHR 121_ ILHRD 126_ MKPQN 131_ ILLAK 136_ GGGIK 141_ LCDFG 146_ FARAM 151_ STNTM 156_ VLTSI 161_ KGTPL 166_ YMSPE 171_ LVEER 176_ PYDHT 181_ ADLWS 186_ VGCIL 191_ YELAV 196_ GTPPF 201_ YATSI 206_ FQLVS 211_ LILKD 216_ PVRWP 221_ STISP 226_ CFKNF 231_ LQGLL 236_ TKDPR 241_ QRLSW 246_ PDLLY 251_ HPFIA 256_ GHVTI 261_ ITEPA 266_ GPDLG 271_ TPFTS 276_ RLPPE 281_ LQVLK 286_ DEQAH 291_ RLAPK 296_ GNQSR 301_ ILTQA 306_ YKRMA 311_ EEAMQ 316_ KKHQN 321_ TGPAL 326_ EQEDK 331_ TSKVA 336_ PGTAP 341_ LPRLG 346_ ATPQE 351_ SSLLA 356_ GILAS 361_ ELKSS 366_ WAKSG 371_ TGEVP 376_ SAPRE 381_ NRTTP 386_ DCERA 391_ FPEER 396_ PEVLG 401_ QRSTD 406_ VVDLE 411_ NEEPD 416_ SDNEW 421_ QHLLE 426_ TTEPV 431_ PIQLK 436_ APLTL 441_ LCNPD 446_ FCQRI 451_ QSQLH 456_ EAGGQ 461_ ILKGI 466_ LEGAS 471_ HILPA 476_ FRVLS 481_ SLLSS 486_ CSDSV 491_ ALYSF 496_ CREAG 501_ LPGLL 506_ LSLLR 511_ HSQES 516_ NSLQQ 521_ QSWYG 526_ TFLQD 531_ LMAVI 536_ QAYFA 541_ CTFNL 546_ ERSQT 551_ SDSLQ 556_ VFQEA 561_ ANLFL 566_ DLLGK 571_ LLAQP 576_ DDSEQ 581_ TLRRD 586_ SLMCF 591_ TVLCE 596_ AMDGN 601_ SRAIS 606_ KAFYS 611_ SLLTT 616_ QQVVL 621_ DGLLH 626_ GLTVP 631_ QLPVH 636_ TPQGA 641_ PQVSQ 646_ PLREQ 651_ SEDIP 656_ GAISS 661_ ALAAI 666_ CTAPV 671_ GLPDC 676_ WDAKE 681_ QVCWH 686_ LANQL 691_ TEDSS 696_ QLRPS 701_ LISGL 706_ QHPIL 711_ CLHLL 716_ KVLYS 721_ CCLVS 726_ EGLCR 731_ LLGQE 736_ PLALE 741_ SLFML 746_ IQGKV 751_ KVVDW 756_ EESTE 761_ VTLYF 766_ LSLLV 771_ FRLQN 776_ LPCGM 781_ EKLGS 786_ DVATL 791_ FTHSH 796_ VVSLV 801_ SAAAC 806_ LLGQL 811_ GQQGV 816_ TFDLQ 821_ PMEWM 826_ AAATH 831_ ALSAP 836_ AEVRL 841_ TPPGS 846_ CGFYD 851_ GLLIL 856_ LLQLL 861_ TEQGK 866_ ASLIR 871_ DMSSS 876_ EMWTV 881_ LWHRF 886_ SMVLR 891_ LPEEA 896_ SAQEG 901_ ELSLS 906_ SPPSP 911_ EPDWT 916_ LISPQ 921_ GMAAL 926_ LSLAM 931_ ATFTQ 936_ EPQLC 941_ LSCLS 946_ QHGSI 951_ LMSIL 956_ KHLLC 961_ PSFLN 966_ QLRQA 971_ PHGSE 976_ FLPVV 981_ VLSVC 986_ QLLCF 991_ PFALD 996_ MDADL 1001_ LIGVL 1006_ ADLRD 1011_ SEVAA 1016_ HLLQV 1021_ CCYHL 1026_ PLMQV 1031_ ELPIS 1036_ LLTRL 1041_ ALMDP 1046_ TSLNQ 1051_ FVNTV 1056_ SASPR 1061_ TIVSF 1066_ LSVAL 1071_ LSDQP 1076_ LLTSD 1081_ LLSLL 1086_ AHTAR 1091_ VLSPS 1096_ HLSFI 1101_ QELLA 1106_ GSDES 1111_ YRPLR 1116_ SLLGH 1121_ PENSV 1126_ RAHTY 1131_ RLLGH 1136_ LLQHS 1141_ MALRG 1146_ ALQSQ 1151_ SGLLS 1156_ LLLLG 1161_ LGDKD 1166_ PVVRC 1171_ SASFA 1176_ VGNAA 1181_ YQAGP 1186_ LGPAL 1191_ AAAVP 1196_ SMTQL 1201_ LGDPQ 1206_ AGIRR 1211_ NVASA 1216_ LGNLG 1221_ PEGLG 1226_ EELLQ 1231_ CEVPQ 1236_ RLLEM 1241_ ACGDP 1246_ QPNVK 1251_ EAALI 1256_ ALRSL 1261_ QQEPG 1266_ IHQVL 1271_ VSLGA 1276_ SEKLS 1281_ LLSLG 1286_ NQSLP 1291_ HSSPR 1296_ PASAK 1301_ HCRKL 1306_IHLLR
1: Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors (PubMed:10806483). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia