Phospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependent phospholipid scramblase 4) (Cell growth-inhibiting gene 43 protein) (TRA1)
1_MSGVV 6_ PTAPE 11_ QPAGE 16_ MENQT 21_ KPPDP 26_ RPDAP 31_ PEYNS 36_ HFLPG 41_ PPGTA 46_ VPPPT 51_ GYPGG 56_ LPMGY 61_ YSPQQ 66_ PSTFP 71_ LYQPV 76_ GGIHP 81_ VRYQP 86_ GKYPM 91_ PNQSV 96_ PITWM 101_ PGPTP 106_ MANCP 111_ PGLEY 116_ LVQLD 121_ NIHVL 126_ QHFEP 131_ LEMMT 136_ CFETN 141_ NRYDI 146_ KNNSD 151_ QMVYI 156_ VTEDT 161_ DDFTR 166_ NAYRT 171_ LRPFV 176_ LRVTD 181_ CMGRE 186_ IMTMQ 191_ RPFRC 196_ TCCCF 201_ CCPSA 206_ RQELE 211_ VQCPP 216_ GVTIG 221_ FVAEH 226_ WNLCR 231_ AVYSI 236_ QNEKK 241_ ENVMR 246_ VRGPC 251_ STYGC 256_ GSDSV 261_ FEVKS 266_ LDGIS 271_ NIGSI 276_ IRKWN 281_ GLLSA 286_ MADAD 291_ HFDIH 296_ FPLDL 301_ DVKMK 306_ AMIFG 311_ ACFLI 316_ DFMYF 321_ERSPP
1: Catalyzes metal ion-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane and participates in the redistribution of phospholipids between membrane leaflets (PubMed:23089641). Metal ions bind to the calcium-binding site and induce conformation change in the protein (PubMed:23089641). Has a greater affi nity for Ca(2+) than Mg(2+) and Zn(2+) (PubMed:23089641)