Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241)
1_MMQGN 6_ TCHRM 11_ SFHPG 16_ RGCPR 21_ GRGGH 26_ GARPS 31_ APSFR 36_ PQNLR 41_ LLHPQ 46_ QPPVQ 51_ YQYEP 56_ PSAPS 61_ TTFSN 66_ SPAPN 71_ FLPPR 76_ PDFVP 81_ FPPPM 86_ PPSAQ 91_ GPLPP 96_ CPIRP 101_ PFPNH 106_ QMRHP 111_ FPVPP 116_ CFPPM 121_ PPPMP 126_ CPNNP 131_ PVPGA 136_ PPGQG 141_ TFPFM 146_ MPPPS 151_ MPHPP 156_ PPPVM 161_ PQQVN 166_ YQYPP 171_ GYSHH 176_ NFPPP 181_ SFNSF 186_ QNNPS 191_ SFLPS 196_ ANNSS 201_ SPHFR 206_ HLPPY 211_ PLPKA 216_ PSERR 221_ SPERL 226_ KHYDD 231_ HRHRD 236_ HSHGR 241_ GERHR 246_ SLDRR 251_ ERGRS 256_ PDRRR 261_ QDSRY 266_ RSDYD 271_ RGRTP 276_ SRHRS 281_ YERSR 286_ ERERE 291_ RHRHR 296_ DNRRS 301_ PSLER 306_ SYKKE 311_ YKRSG 316_ RSYGL 321_ SVVPE 326_ PAGCT 331_ PELPG 336_ EIIKN 341_ TDSWA 346_ PPLEI 351_ VNHRS 356_ PSREK 361_ KRARW 366_ EEEKD 371_ RWSDN 376_ QSSGK 381_ DKNYT 386_ SIKEK 391_ EPEET 396_ MPDKN 401_ EEEEE 406_ ELLKP 411_ VWIRC 416_ THSEN 421_ YYSSD 426_ PMDQV 431_ GDSTV 436_ VGTSR 441_ LRDLY 446_ DKFEE 451_ ELGSR 456_ QEKAK 461_ AARPP 466_ WEPPK 471_ TKLDE 476_ DLESS 481_ SESEC 486_ ESDED 491_ STCSS 496_ SSDSE 501_ VFDVI 506_ AEIKR 511_ KKAHP 516_ DRLHD 521_ ELWYN 526_ DPGQM 531_ NDGPL 536_ CKCSA 541_ KARRT 546_ GIRHS 551_ IYPGE 556_ EAIKP 561_ CRPMT 566_ NNAGR 571_ LFHYR 576_ ITVSP 581_ PTNFL 586_ TDRPT 591_ VIEYD 596_ DHEYI 601_ FEGFS 606_ MFAHA 611_ PLTNI 616_ PLCKV 621_ IRFNI 626_ DYTIH 631_ FIEEM 636_ MPENF 641_ CVKGL 646_ ELFSL 651_ FLFRD 656_ ILELY 661_ DWNLK 666_ GPLFE 671_ DSPPC 676_ CPRFH 681_ FMPRF 686_ VRFLP 691_ DGGKE 696_ VLSMH 701_ QILLY 706_ LLRCS 711_ KALVP 716_ EEEIA 721_ NMLQW 726_ EELEW 731_ QKYAE 736_ ECKGM 741_ IVTNP 746_ GTKPS 751_ SVRID 756_ QLDRE 761_ QFNPD 766_ VITFP 771_ IIVHF 776_ GIRPA 781_ QLSYA 786_ GDPQY 791_ QKLWK 796_ SYVKL 801_ RHLLA 806_ NSPKV 811_ KQTDK 816_ QKLAQ 821_ REEAL 826_ QKIRQ 831_ KNTMR 836_ REVTV 841_ ELSSQ 846_ GFWKT 851_ GIRSD 856_ VCQHA 861_ MMLPV 866_ LTHHI 871_ RYHQC 876_ LMHLD 881_ KLIGY 886_ TFQDR 891_ CLLQL 896_ AMTHP 901_ SHHLN 906_ FGMNP 911_ DHARN 916_ SLSNC 921_ GIRQP 926_ KYGDR 931_ KVHHM 936_ HMRKK 941_ GINTL 946_ INIMS 951_ RLGQD 956_ DPTPS 961_ RINHN 966_ ERLEF 971_ LGDAV 976_ VEFLT 981_ SVHLY 986_ YLFPS 991_ LEEGG 996_ LATYR 1001_ TAIVQ 1006_ NQHLA 1011_ MLAKK 1016_ LELDR 1021_ FMLYA 1026_ HGPDL 1031_ CRESD 1036_ LRHAM 1041_ ANCFE 1046_ ALIGA 1051_ VYLEG 1056_ SLEEA 1061_ KQLFG 1066_ RLLFN 1071_ DPDLR 1076_ EVWLN 1081_ YPLHP 1086_ LQLQE 1091_ PNTDR 1096_ QLIET 1101_ SPVLQ 1106_ KLTEF 1111_ EEAIG 1116_ VIFTH 1121_ VRLLA 1126_ RAFTL 1131_ RTVGF 1136_ NHLTL 1141_ GHNQR 1146_ MEFLG 1151_ DSIMQ 1156_ LVATE 1161_ YLFIH 1166_ FPDHH 1171_ EGHLT 1176_ LLRSS 1181_ LVNNR 1186_ TQAKV 1191_ AEELG 1196_ MQEYA 1201_ ITNDK 1206_ TKRPV 1211_ ALRTK 1216_ TLADL 1221_ LESFI 1226_ AALYI 1231_ DKDLE 1236_ YVHTF 1241_ MNVCF 1246_ FPRLK 1251_ EFILN 1256_ QDWND 1261_ PKSQL 1266_ QQCCL 1271_ TLRTE 1276_ GKEPD 1281_ IPLYK 1286_ TLQTV 1291_ GPSHA 1296_ RTYTV 1301_ AVYFK 1306_ GERIG 1311_ CGKGP 1316_ SIQQA 1321_ EMGAA 1326_ MDALE 1331_ KYNFP 1336_ QMAHQ 1341_ KRFIE 1346_ RKYRQ 1351_ ELKEM 1356_ RWERE 1361_ HQERE 1366_PDETE
1: Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies. Plays a role in growth homeostasis in response to autophagy in motor neurons (By similarity)