Phosphatidylinositol polyphosphate 5-phosphatase type IV (72 kDa inositol polyphosphate 5-phosphatase) (Inositol polyphosphate-5-phosphatase E) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86)
1_MPSKA 6_ ENLRP 11_ SEPAP 16_ QPPEG 21_ RTLQG 26_ QLPGA 31_ PPAQR 36_ AGSPP 41_ DAPGS 46_ ESPAL 51_ ACSTP 56_ ATPSG 61_ EDPPA 66_ RAAPI 71_ APRPP 76_ ARPRL 81_ ERALS 86_ LDDKG 91_ WRRRR 96_ FRGSQ 101_ EDLEA 106_ RNGTS 111_ PSRGS 116_ VQSEG 121_ PGAPA 126_ HSCSP 131_ PCLST 136_ SLQEI 141_ PKSRG 146_ VLSSE 151_ RGSPS 156_ SGGNP 161_ LSGVA 166_ SSSPN 171_ LPHRD 176_ AAVAG 181_ SSPRL 186_ PSLLP 191_ PRPPP 196_ ALSLD 201_ IASDS 206_ LRTAN 211_ KVDSD 216_ LADYK 221_ LRAQP 226_ LLVRA 231_ HSSLG 236_ PGRPR 241_ SPLAC 246_ DDCSL 251_ RSAKS 256_ SFSLL 261_ APIRS 266_ KDVRS 271_ RSYLE 276_ GSLLA 281_ SGALL 286_ GADEL 291_ ARYFP 296_ DRNVA 301_ LFVAT 306_ WNMQG 311_ QKELP 316_ PSLDE 321_ FLLPA 326_ EADYA 331_ QDLYV 336_ IGVQE 341_ GCSDR 346_ REWET 351_ RLQET 356_ LGPHY 361_ VLLSS 366_ AAHGV 371_ LYMSL 376_ FIRRD 381_ LIWFC 386_ SEVEC 391_ STVTT 396_ RIVSQ 401_ IKTKG 406_ ALGIS 411_ FTFFG 416_ TSFLF 421_ ITSHF 426_ TSGDG 431_ KVAER 436_ LLDYT 441_ RTVQA 446_ LVLPR 451_ NVPDT 456_ NPYRS 461_ SAADV 466_ TTRFD 471_ EVFWF 476_ GDFNF 481_ RLSGG 486_ RTVVD 491_ ALLCQ 496_ GLVVD 501_ VPALL 506_ QHDQL 511_ IREMR 516_ KGSIF 521_ KGFQE 526_ PDIHF 531_ LPSYK 536_ FDIGK 541_ DTYDS 546_ TSKQR 551_ TPSYT 556_ DRVLY 561_ RSRHK 566_ GDICP 571_ VSYSS 576_ CPGIK 581_ TSDHR 586_ PVYGL 591_ FRVKV 596_ RPGRD 601_ NIPLA 606_ AGKFD 611_ RELYL 616_ LGIKR 621_ RISKE 626_ IQRQQ 631_ ALQSQ 636_NSSTI
1: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity) (PubMed:10764818). Specific for lipid substrates, inactive towards water soluble inositol phosphates (PubMed:10764818). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (By similarity)