Transmembrane protease serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (CAPH2) (Membrane-type serine protease 2) (MT-SP2) [Cleaved into: Transmembrane protease serine 4 catalytic chain]
1_MLQDP 6_ DSDQP 11_ LNSLD 16_ VKPLR 21_ KPRIP 26_ METFR 31_ KVGIP 36_ IIIAL 41_ LSLAS 46_ IIIVV 51_ VLIKV 56_ ILDKY 61_ YFLCG 66_ QPLHF 71_ IPRKQ 76_ LCDGE 81_ LDCPL 86_ GEDEE 91_ HCVKS 96_ FPEGP 101_ AVAVR 106_ LSKDR 111_ STLQV 116_ LDSAT 121_ GNWFS 126_ ACFDN 131_ FTEAL 136_ AETAC 141_ RQMGY 146_ SSKPT 151_ FRAVE 156_ IGPDQ 161_ DLDVV 166_ EITEN 171_ SQELR 176_ MRNSS 181_ GPCLS 186_ GSLVS 191_ LHCLA 196_ CGKSL 201_ KTPRV 206_ VGVEE 211_ ASVDS 216_ WPWQV 221_ SIQYD 226_ KQHVC 231_ GGSIL 236_ DPHWV 241_ LTAAH 246_ CFRKH 251_ TDVFN 256_ WKVRA 261_ GSDKL 266_ GSFPS 271_ LAVAK 276_ IIIIE 281_ FNPMY 286_ PKDND 291_ IALMK 296_ LQFPL 301_ TFSGT 306_ VRPIC 311_ LPFFD 316_ EELTP 321_ ATPLW 326_ IIGWG 331_ FTKQN 336_ GGKMS 341_ DILLQ 346_ ASVQV 351_ IDSTR 356_ CNADD 361_ AYQGE 366_ VTEKM 371_ MCAGI 376_ PEGGV 381_ DTCQG 386_ DSGGP 391_ LMYQS 396_ DQWHV 401_ VGIVS 406_ WGYGC 411_ GGPST 416_ PGVYT 421_ KVSAY 426_ LNWIY 431_NVWKA
1: Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (PubMed:24434139). Seems to be capable of activating ENaC (By similarity)
2: (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry