Ras-related protein Rab-6B (EC 3.6.5.2)
1_MSAGG 6_ DFGNP 11_ LRKFK 16_ LVFLG 21_ EQSVG 26_ KTSLI 31_ TRFMY 36_ DSFDN 41_ TYQAT 46_ IGIDF 51_ LSKTM 56_ YLEDR 61_ TVRLQ 66_ LWDTA 71_ GQERF 76_ RSLIP 81_ SYIRD 86_ STVAV 91_ VVYDI 96_ TNLNS 101_ FQQTS 106_ KWIDD 111_ VRTER 116_ GSDVI 121_ IMLVG 126_ NKTDL 131_ ADKRQ 136_ ITIEE 141_ GEQRA 146_ KELSV 151_ MFIET 156_ SAKTG 161_ YNVKQ 166_ LFRRV 171_ ASALP 176_ GMENV 181_ QEKSK 186_ EGMID 191_ IKLDK 196_ PQEPP 201_ASEGG
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (By similarity). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Regulates the compacted morphology of the Golgi (PubMed:26209634). Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369). Plays a role in neuron projection development (PubMed:25492866)