Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x)
1_MGNGM 6_ NKILP 11_ GLYIG 16_ NFKDA 21_ RDAEQ 26_ LSKNK 31_ VTHIL 36_ SVHDS 41_ ARPML 46_ EGVKY 51_ LCIPA 56_ ADSPS 61_ QNLTR 66_ HFKES 71_ IKFIH 76_ ECRLR 81_ GESCL 86_ VHCLA 91_ GVSRS 96_ VTLVI 101_ AYIMT 106_ VTDFG 111_ WEDAL 116_ HTVRA 121_ GRSCA 126_ NPNVG 131_ FQRQL 136_ QEFEK 141_ HEVHQ 146_ YRQWL 151_ KEEYG 156_ ESPLQ 161_ DAEEA 166_ KNILA 171_ APGIL 176_KFWAF
1: Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues (PubMed:24714587, PubMed:38225265). Activates the JNK signaling pathway (PubMed:11717427). Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2 (PubMed:24714587, PubMed:38225265). Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2 (PubMed:38225265). Dephosphorylates and thereby inactivates tyrosine kinase LCK (PubMed:24714587). Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK (PubMed:38225265). May play a role in B-cell receptor (BCR) signaling and B-cell function (By similarity)