Phospholipid scramblase 3 (PL scramblase 3) (Ca(2+)-dependent phospholipid scramblase 3)
1_MAGYL 6_ PPKGY 11_ APSPP 16_ PPYPV 21_ TPGYP 26_ EPALH 31_ PGPGQ 36_ APVPA 41_ QVPAP 46_ APGFA 51_ LFPSP 56_ GPVAL 61_ GSAAP 66_ FLPLP 71_ GVPSG 76_ LEFLV 81_ QIDQI 86_ LIHQK 91_ AERVE 96_ TFLGW 101_ ETCNR 106_ YELRS 111_ GAGQP 116_ LGQAA 121_ EESNC 126_ CARLC 131_ CGARR 136_ PLRVR 141_ LADPG 146_ DREVL 151_ RLLRP 156_ LHCGC 161_ SCCPC 166_ GLQEM 171_ EVQAP 176_ PGTTI 181_ GHVLQ 186_ TWHPF 191_ LPKFS 196_ IQDAD 201_ RQTVL 206_ RVVGP 211_ CWTCG 216_ CGTDT 221_ NFEVK 226_ TRDES 231_ RSVGR 236_ ISKQW 241_ GGLVR 246_ EALTD 251_ ADDFG 256_ LQFPL 261_ DLDVR 266_ VKAVL 271_ LGATF 276_ LIDYM 281_ FFEKR 286_GGAGP
1: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:29337693, PubMed:31769662). Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (PubMed:12649167, PubMed:14573790, PubMed:17226776, PubMed:18358005). Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (PubMed:14573790, PubMed:17226776, PubMed:18358005). Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (PubMed:18491232). Regulates cardiolipin de novo biosynthesis and its resynthesis (PubMed:16939411)