Glutaredoxin-2, mitochondrial
1_MIWRR 6_ AALAG 11_ TRLVW 16_ SRSGS 21_ AGWLD 26_ RAAGA 31_ AGAAA 36_ AAASG 41_ MESNT 46_ SSSLE 51_ NLATA 56_ PVNQI 61_ QETIS 66_ DNCVV 71_ IFSKT 76_ SCSYC 81_ TMAKK 86_ LFHDM 91_ NVNYK 96_ VVELD 101_ LLEYG 106_ NQFQD 111_ ALYKM 116_ TGERT 121_ VPRIF 126_ VNGTF 131_ IGGAT 136_ DTHRL 141_ HKEGK 146_ LLPLV 151_ HQCYL 156_KKSKR
1: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release