Ras association domain-containing protein 1
1_MSGEP 6_ ELIEL 11_ RELAP 16_ AGRAG 21_ KGRTR 26_ LERAN 31_ ALRIA 36_ RGTAC 41_ NPTRQ 46_ LVPGR 51_ GHRFQ 56_ PAGPA 61_ THTWC 66_ DLCGD 71_ FIWGV 76_ VRKGL 81_ QCARL 86_ SADCK 91_ FTCHY 96_ RCRAL 101_ VCLDC 106_ CGPRD 111_ LGWEP 116_ AVERD 121_ TNVDE 126_ PVEWE 131_ TPDLS 136_ QAEIE 141_ QKIKE 146_ YNAQI 151_ NSNLF 156_ MSLNK 161_ DGSYT 166_ GFIKV 171_ QLKLV 176_ RPVSV 181_ PSSKK 186_ PPSLQ 191_ DARRG 196_ PGRGT 201_ SVRRR 206_ TSFYL 211_ PKDAV 216_ KHLHV 221_ LSRTR 226_ AREVI 231_ EALLR 236_ KFLVV 241_ DDPRK 246_ FALFE 251_ RAERH 256_ GQVYL 261_ RKLLD 266_ DEQPL 271_ RLRLL 276_ AGPSD 281_ KALSF 286_ VLKEN 291_ DSGEV 296_ NWDAF 301_ SMPEL 306_ HNFLR 311_ ILQRE 316_ EEEHL 321_ RQILQ 326_ KYSYC 331_ RQKIQ 336_EALHA
1: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage