CREB/ATF bZIP transcription factor (Host cell factor-binding transcription factor Zhangfei) (HCF-binding transcription factor Zhangfei)
1_MRHSL 6_ TKLLA 11_ ASGSN 16_ SPTRS 21_ ESPEP 26_ AATCS 31_ LPSDL 36_ TRAAA 41_ GEEET 46_ AAAGS 51_ PGRKQ 56_ QFGDE 61_ GELEA 66_ GRGSR 71_ GGVAV 76_ RAPSP 81_ EEMEE 86_ EAIAS 91_ LPGEE 96_ TEDMD 101_ FLSGL 106_ ELADL 111_ LDPRQ 116_ PDWHL 121_ DPGLS 126_ SPGPL 131_ SSSGG 136_ GSDSG 141_ GLWRG 146_ DDDDE 151_ AAAAE 156_ MQRFS 161_ DLLQR 166_ LLNGI 171_ GGCSS 176_ SSDSG 181_ SAEKR 186_ RRKSP 191_ GGGGG 196_ GGSGN 201_ DNNQA 206_ ATKSP 211_ RKAAA 216_ AAARL 221_ NRLKK 226_ KEYVM 231_ GLESR 236_ VRGLA 241_ AENQE 246_ LRAEN 251_ RELGK 256_ RVQAL 261_ QEESR 266_ YLRAV 271_ LANET 276_ GLARL 281_ LSRLS 286_ GVGLR 291_ LTTSL 296_ FRDSP 301_ AGDHD 306_ YALPV 311_ GKQKQ 316_ DLLEE 321_ DDSAG 326_ GVCLH 331_ VDKDK 336_ VSVEF 341_ CSACA 346_RKASS
1: Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells