E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3)
1_MGSQP 6_ PLGSP 11_ LSREE 16_ GEAPP 21_ PAPAS 26_ EGRRR 31_ SRRVR 36_ LRGSC 41_ RHRPS 46_ FLGCR 51_ ELAAS 56_ APARP 61_ APASS 66_ EIMAS 71_ AAKEF 76_ KMDNF 81_ SPKAG 86_ TSKLQ 91_ QTVPA 96_ DASPD 101_ SKCPI 106_ CLDRF 111_ DNVSY 116_ LDRCL 121_ HKFCF 126_ RCVQE 131_ WSKNK 136_ AECPL 141_ CKQPF 146_ DSIFH 151_ SVRAE 156_ DDFKE 161_ YVLRP 166_ SYNGS 171_ FVTPD 176_ RRFRY 181_ RTTLT 186_ RERNA 191_ SVYSP 196_ SGPVN 201_ RRTTT 206_ PPDSG 211_ VLFEG 216_ LGIST 221_ RPRDV 226_ EIPQF 231_ MRQIA 236_ VRRPT 241_ TADER 246_ SLRKI 251_ QEQDI 256_ INFRR 261_ TLYRA 266_ GARVR 271_ NIEDG 276_ GRYRD 281_ ISAEF 286_ FRRNP 291_ ACLHR 296_ LVPWL 301_ KRELT 306_ VLFGA 311_ HGSLV 316_ NIVQH 321_ IIMSN 326_ VTRYD 331_ LESQA 336_ FVSDL 341_ RPFLL 346_ NRTEH 351_ FIHEF 356_ ISFAR 361_ SPFNM 366_ AAFDQ 371_ HANYD 376_ CPAPS 381_ YEEGS 386_ HSDSS 391_ VITIS 396_ PDEAE 401_ TQELD 406_ INVAT 411_ VSQAP 416_ WDDET 421_ PGPSY 426_ SSSEQ 431_ VHVTM 436_ SSLLN 441_ TSDSS 446_ DEELV 451_ TGGAT 456_ SQIQG 461_ VQTND 466_ DLNND 471_ SDDSS 476_ DNCVI 481_ VGFVK 486_ PLAER 491_ TPELV 496_ ELSSD 501_ SEDLG 506_ SYEKM 511_ ETVKT 516_ QEQEQ 521_ SYSSG 526_ DSDVS 531_ RCSSP 536_ HSVLG 541_ KDEQI 546_ NKGHC 551_ DSSTR 556_ IKSKK 561_ EEKRS 566_ TSLSS 571_ PRNLN 576_ SSVRG 581_ DRVYS 586_ PYNHR 591_ HRKRG 596_ RSRSS 601_ DSRSQ 606_ SRSGH 611_ DQKNH 616_ RKHHG 621_ KKRMK 626_ SKRSR 631_ SRESS 636_ RPRGR 641_ RDKKR 646_ SRTRD 651_ SSWSR 656_ RSQTL 661_ SLSSE 666_ STSRS 671_ RSRSS 676_ DHGKR 681_ RSRSR 686_ NRDRY 691_ YLRNN 696_ YGSRY 701_ KWEYT 706_ YYSRN 711_ KDRDG 716_ YESSY 721_ RRRTL 726_ SRAHY 731_ SRQSS 736_ SPEFR 741_ VQSFS 746_ ERTNA 751_ RKKNN 756_ HSERK 761_ YYYYE 766_ RHRSR 771_ SLSSN 776_ RSRTA 781_ STGTD 786_ RVRNE 791_ KPGGK 796_ RKYKT 801_ RHLEG 806_ TNEVA 811_ QPSRE 816_ FASKA 821_ KDSHY 826_ QKSSS 831_ KLDGN 836_ YKNES 841_ DTFSD 846_ SRSSD 851_ RETKH 856_ KRRKR 861_ KTRSL 866_ SVEIV 871_ YEGKA 876_ TDTTK 881_ HHKKK 886_ KKKHK 891_ KKHKK 896_ HHGDN 901_ ASRSP 906_ VVITI 911_ DSDSD 916_ KDSEV 921_ KEDTE 926_ CDNSG 931_ PQDPL 936_ QNEFL 941_ APSLE 946_ PFETK 951_ DVVTI 956_ EAEFG 961_ VLDKE 966_ CDIAT 971_ LSNNL 976_ NNANK 981_ TVDNI 986_ PPLAA 991_ SVEQT 996_ LDVRE 1001_ ESTFV 1006_ SDLEN 1011_ QPSNI 1016_ VSLQT 1021_ EPSRQ 1026_ LPSPR 1031_ TSLMS 1036_VCLGR
1: Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation