Cysteinyl leukotriene receptor 2 (CysLTR2) (G-protein coupled receptor GPCR21) (hGPCR21) (G-protein coupled receptor HG57) (HPN321)
1_MERKF 6_ MSLQP 11_ SISVS 16_ EMEPN 21_ GTFSN 26_ NNSRN 31_ CTIEN 36_ FKREF 41_ FPIVY 46_ LIIFF 51_ WGVLG 56_ NGLSI 61_ YVFLQ 66_ PYKKS 71_ TSVNV 76_ FMLNL 81_ AISDL 86_ LFIST 91_ LPFRA 96_ DYYLR 101_ GSNWI 106_ FGDLA 111_ CRIMS 116_ YSLYV 121_ NMYSS 126_ IYFLT 131_ VLSVV 136_ RFLAM 141_ VHPFR 146_ LLHVT 151_ SIRSA 156_ WILCG 161_ IIWIL 166_ IMASS 171_ IMLLD 176_ SGSEQ 181_ NGSVT 186_ SCLEL 191_ NLYKI 196_ AKLQT 201_ MNYIA 206_ LVVGC 211_ LLPFF 216_ TLSIC 221_ YLLII 226_ RVLLK 231_ VEVPE 236_ SGLRV 241_ SHRKA 246_ LTTII 251_ ITLII 256_ FFLCF 261_ LPYHT 266_ LRTVH 271_ LTTWK 276_ VGLCK 281_ DRLHK 286_ ALVIT 291_ LALAA 296_ ANACF 301_ NPLLY 306_ YFAGE 311_ NFKDR 316_ LKSAL 321_ RKGHP 326_ QKAKT 331_ KCVFP 336_ VSVWL 341_RKETR
1: Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4