Asc-type amino acid transporter 1 (Asc-1) (Solute carrier family 7 member 10)
1_MAGHT 6_ QQPSG 11_ RGNPR 16_ PAPSP 21_ SPVPG 26_ TVPGA 31_ SERVA 36_ LKKEI 41_ GLLSA 46_ CTIII 51_ GNIIG 56_ SGIFI 61_ SPKGV 66_ LEHSG 71_ SVGLA 76_ LFVWV 81_ LGGGV 86_ TALGS 91_ LCYAE 96_ LGVAI 101_ PKSGG 106_ DYAYV 111_ TEIFG 116_ GLAGF 121_ LLLWS 126_ AVLIM 131_ YPTSL 136_ AVISM 141_ TFSNY 146_ VLQPV 151_ FPNCI 156_ PPTTA 161_ SRVLS 166_ MACLM 171_ LLTWV 176_ NSSSV 181_ RWATR 186_ IQDMF 191_ TGGKL 196_ LALSL 201_ IIGVG 206_ LLQIF 211_ QGHFE 216_ ELRPS 221_ NAFAF 226_ WMTPS 231_ VGHLA 236_ LAFLQ 241_ GSFAF 246_ SGWNF 251_ LNYVT 256_ EEMVD 261_ ARKNL 266_ PRAIF 271_ ISIPL 276_ VTFVY 281_ TFTNI 286_ AYFTA 291_ MSPQE 296_ LLSSN 301_ AVAVT 306_ FGEKL 311_ LGYFS 316_ WVMPV 321_ SVALS 326_ TFGGI 331_ NGYLF 336_ TYSRL 341_ CFSGA 346_ REGHL 351_ PSLLA 356_ MIHVR 361_ HCTPI 366_ PALLV 371_ CCGAT 376_ AVIML 381_ VGDTY 386_ TLINY 391_ VSFIN 396_ YLCYG 401_ VTILG 406_ LLLLR 411_ WRRPA 416_ LHRPI 421_ KVNLL 426_ IPVAY 431_ LVFWA 436_ FLLVF 441_ SFISE 446_ PMVCG 451_ VGVII 456_ ILTGV 461_ PIFFL 466_ GVFWR 471_ SKPKC 476_ VHRLT 481_ ESMTH 486_ WGQEL 491_ CFVVY 496_ PQDAP 501_ EEEEN 506_ GPCPP 511_ SLLPA 516_TDKPS
1: Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion (By similarity) (PubMed:10863037). Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons (By similarity). At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission (By similarity). May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment (By similarity)