E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18)
1_MDSLA 6_ ESRWP 11_ PGLAV 16_ MKTID 21_ DLLRC 26_ GICFE 31_ YFNIA 36_ MIIPQ 41_ CSHNY 46_ CSLCI 51_ RKFLS 56_ YKTQC 61_ PTCCV 66_ TVTEP 71_ DLKNN 76_ RILDE 81_ LVKSL 86_ NFARN 91_ HLLQF 96_ ALESP 101_ AKSPA 106_ SSSSK 111_ NLAVK 116_ VYTPV 121_ ASRQS 126_ LKQGS 131_ RLMDN 136_ FLIRE 141_ MSGST 146_ SELLI 151_ KENKS 156_ KFSPQ 161_ KEASP 166_ AAKTK 171_ ETRSV 176_ EEIAP 181_ DPSEA 186_ KRPEP 191_ PSTST 196_ LKQVT 201_ KVDCP 206_ VCGVN 211_ IPESH 216_ INKHL 221_ DSCLS 226_ REEKK 231_ ESLRS 236_ SVHKR 241_ KPLPK 246_ TVYNL 251_ LSDRD 256_ LKKKL 261_ KEHGL 266_ SIQGN 271_ KQQLI 276_ KRHQE 281_ FVHMY 286_ NAQCD 291_ ALHPK 296_ SAAEI 301_ VREIE 306_ NIEKT 311_ RMRLE 316_ ASKLN 321_ ESVMV 326_ FTKDQ 331_ TEKEI 336_ DEIHS 341_ KYRKK 346_ HKSEF 351_ QLLVD 356_ QARKG 361_ YKKIA 366_ GMSQK 371_ TVTIT 376_ KEDES 381_ TEKLS 386_ SVCMG 391_ QEDNM 396_ TSVTN 401_ HFSQS 406_ KLDSP 411_ EELEP 416_ DREED 421_ SSSCI 426_ DIQEV 431_ LSSSE 436_ SDSCN 441_ SSSSD 446_ IIRDL 451_ LEEEE 456_ AWEAS 461_ HKNDL 466_ QDTEI 471_ SPRQN 476_ RRTRA 481_ AESAE 486_IEPRN
1: E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity