Transmembrane 7 superfamily member 3 (Seven span transmembrane protein)
1_MGFLQ 6_ LLVVA 11_ VLASE 16_ HRVAG 21_ AAEVF 26_ GNSSE 31_ GLIEF 36_ SVGKF 41_ RYFEL 46_ NRPFP 51_ EEAIL 56_ HDISS 61_ NVTFL 66_ IFQIH 71_ SQYQN 76_ TTVSF 81_ SPTLL 86_ SNSSE 91_ TGTAS 96_ GLVFI 101_ LRPEQ 106_ STCTW 111_ YLGTS 116_ GIQPV 121_ QNMAI 126_ LLSYS 131_ ERDPV 136_ PGGCN 141_ LEFDL 146_ DIDPN 151_ IYLEY 156_ NFFET 161_ TIKFA 166_ PANLG 171_ YARGV 176_ DPPPC 181_ DAGTD 186_ QDSRW 191_ RLQYD 196_ VYQYF 201_ LPEND 206_ LTEEM 211_ LLKHL 216_ QRMVS 221_ VPQVK 226_ ASALK 231_ VVTLT 236_ ANDKT 241_ SVSFS 246_ SLPGQ 251_ GVIYN 256_ VIVWD 261_ PFLNT 266_ SAAYI 271_ PAHTY 276_ ACSFE 281_ AGEGS 286_ CASLG 291_ RVSSK 296_ VFFTL 301_ FALLG 306_ FFICF 311_ FGHRF 316_ WKTEL 321_ FFIGF 326_ IIMGF 331_ FFYIL 336_ ITRLT 341_ PIKYD 346_ VNLIL 351_ TAVTG 356_ SVGGM 361_ FLVAV 366_ WWRFG 371_ ILSIC 376_ MLCVG 381_ LVLGF 386_ LISSV 391_ TFFTP 396_ LGNLK 401_ IFHDD 406_ GVFWV 411_ TFSCI 416_ AILIP 421_ VVFMG 426_ CLRIL 431_ NILTC 436_ GVIGS 441_ YSVVL 446_ AIDSY 451_ WSTSL 456_ SYITL 461_ NVLKR 466_ ALNKD 471_ FHRAF 476_ TNVPF 481_ QTNDF 486_ IILAV 491_ WGMLA 496_ VSGIT 501_ LQIRR 506_ ERGRP 511_ FFPPH 516_ PYKLW 521_ KQERE 526_ RRVTN 531_ ILDPS 536_ YHIPP 541_ LRERL 546_ YGRLT 551_ QIKGL 556_ FQKEQ 561_PAGER
1: Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623)