Solute carrier family 22 member 11 (Organic anion transporter 4)
1_MAFSK 6_ LLEQA 11_ GGVGL 16_ FQTLQ 21_ VLTFI 26_ LPCLM 31_ IPSQM 36_ LLENF 41_ SAAIP 46_ GHRCW 51_ THMLD 56_ NGSAV 61_ STNMT 66_ PKALL 71_ TISIP 76_ PGPNQ 81_ GPHQC 86_ RRFRQ 91_ PQWQL 96_ LDPNA 101_ TATSW 106_ SEADT 111_ EPCVD 116_ GWVYD 121_ RSVFT 126_ STIVA 131_ KWDLV 136_ CSSQG 141_ LKPLS 146_ QSIFM 151_ SGILV 156_ GSFIW 161_ GLLSY 166_ RFGRK 171_ PMLSW 176_ CCLQL 181_ AVAGT 186_ STIFA 191_ PTFVI 196_ YCGLR 201_ FVAAF 206_ GMAGI 211_ FLSSL 216_ TLMVE 221_ WTTTS 226_ RRAVT 231_ MTVVG 236_ CAFSA 241_ GQAAL 246_ GGLAF 251_ ALRDW 256_ RTLQL 261_ AASVP 266_ FFAIS 271_ LISWW 276_ LPESA 281_ RWLII 286_ KGKPD 291_ QALQE 296_ LRKVA 301_ RINGH 306_ KEAKN 311_ LTIEV 316_ LMSSV 321_ KEEVA 326_ SAKEP 331_ RSVLD 336_ LFCVP 341_ VLRWR 346_ SCAML 351_ VVNFS 356_ LLISY 361_ YGLVF 366_ DLQSL 371_ GRDIF 376_ LLQAL 381_ FGAVD 386_ FLGRA 391_ TTALL 396_ LSFLG 401_ RRTIQ 406_ AGSQA 411_ MAGLA 416_ ILANM 421_ LVPQD 426_ LQTLR 431_ VVFAV 436_ LGKGC 441_ FGISL 446_ TCLTI 451_ YKAEL 456_ FPTPV 461_ RMTAD 466_ GILHT 471_ VGRLG 476_ AMMGP 481_ LILMS 486_ RQALP 491_ LLPPL 496_ LYGVI 501_ SIASS 506_ LVVLF 511_ FLPET 516_ QGLPL 521_ PDTIQ 526_ DLESQ 531_ KSTAA 536_ QGNRQ 541_EAVTV
1: Antiporter that mediates the transport of conjugated steroids and other specific organic anions at the basal membrane of syncytiotrophoblast and at the apical membrane of proximal tubule epithelial cells, in exchange for anionic compounds (PubMed:10660625, PubMed:11907186, PubMed:15037815, PubMed:15102942, PubMed:15291761, PubMed:15576633, PubMed:17229912, PubMed:18501590, PubMed:26277985, PubMed:28027879). May be responsible for placental absorption of fetal-derived steroid sulfates such as estrone sulfate (E1S) and the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S), as well as clearing waste products and xenobiotics from the fetus (PubMed:12409283). Maybe also be involved in placental urate homeostasis (PubMed:17229912). Facilitates the renal reabsorption of organic anions such as urate and derived steroid sulfates (PubMed:15037815, PubMed:17229912). Organic anion glutarate acts as conteranion for E1S renal uptake (PubMed:15037815, PubMed:17229912). Possible transport mode may also include DHEA-S/E1S exchange (PubMed:28027879). Also interacts with inorganic anions such as chloride and hydroxyl ions, therefore possible transport modes may include E1S/Cl(-), E1S/OH(-), urate/Cl(-) and urate/OH(-) (PubMed:17229912). Also mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (PubMed:11907186). Also able to uptake anionic drugs, diuretics, bile salts and ochratoxin A (PubMed:10660625, PubMed:26277985). Mediates the unidirectional efflux of glutamate and aspartate (PubMed:28027879). Glutamate efflux down its transmembrane gradient may drive SLC22A11/OAT4-mediated placental uptake of E1S (PubMed:26277985)