Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1)
1_MAAGL 6_ ATWLP 11_ FARAA 16_ AVGWL 21_ PLAQQ 26_ PLPPA 31_ PGVKA 36_ SRGDE 41_ VLVVN 46_ VSGRR 51_ FETWK 56_ NTLDR 61_ YPDTL 66_ LGSSE 71_ KEFFY 76_ DADSG 81_ EYFFD 86_ RDPDM 91_ FRHVL 96_ NFYRT 101_ GRLHC 106_ PRQEC 111_ IQAFD 116_ EELAF 121_ YGLVP 126_ ELVGD 131_ CCLEE 136_ YRDRK 141_ KENAE 146_ RLAED 151_ EEAEQ 156_ AGDGP 161_ ALPAG 166_ SSLRQ 171_ RLWRA 176_ FENPH 181_ TSTAA 186_ LVFYY 191_ VTGFF 196_ IAVSV 201_ IANVV 206_ ETIPC 211_ RGSAR 216_ RSSRE 221_ QPCGE 226_ RFPQA 231_ FFCMD 236_ TACVL 241_ IFTGE 246_ YLLRL 251_ FAAPS 256_ RCRFL 261_ RSVMS 266_ LIDVV 271_ AILPY 276_ YIGLL 281_ VPKND 286_ DVSGA 291_ FVTLR 296_ VFRVF 301_ RIFKF 306_ SRHSQ 311_ GLRIL 316_ GYTLK 321_ SCASE 326_ LGFLL 331_ FSLTM 336_ AIIIF 341_ ATVMF 346_ YAEKG 351_ TNKTN 356_ FTSIP 361_ AAFWY 366_ TIVTM 371_ TTLGY 376_ GDMVP 381_ STIAG 386_ KIFGS 391_ ICSLS 396_ GVLVI 401_ ALPVP 406_ VIVSN 411_ FSRIY 416_ HQNQR 421_ ADKRR 426_ AQQKV 431_ RLARI 436_ RLAKS 441_ GTTNA 446_ FLQYK 451_ QNGGL 456_ EDSGS 461_ GEEQA 466_ LCVRN 471_ RSAFE 476_ QQHHH 481_ LLHCL 486_ EKTTC 491_ HEFTD 496_ ELTFS 501_ EALGA 506_ VSPGG 511_ RTSRS 516_ TSVSS 521_ QPVGP 526_ GSLLS 531_ SCCPR 536_ RAKRR 541_ AIRLA 546_ NSTAS 551_ VSRGS 556_ MQELD 561_ MLAGL 566_ RRSHA 571_ PQSRS 576_ SLNAK 581_ PHDSL 586_ DLNCD 591_ SRDFV 596_ AAIIS 601_ IPTPP 606_ ANTPD 611_ ESQPS 616_ SPGGG 621_ GRAGS 626_ TLRNS 631_ SLGTP 636_ CLFPE 641_TVKIS
1: A-type voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes in the brain (PubMed:15454437). Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons. Exhibits a low-threshold A-type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative potentials. May regulates repetitive firing rates in the suprachiasmatic nucleus (SCN) neurons and circadian rhythms in neuronal excitability and behavior. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity. The regulatory subunit KCNIP1 modulates the kinetics of channel inactivation, increases the current amplitudes and accelerates recovery from inactivation, shifts activation in a depolarizing direction (By similarity). The regulatory subunit DPP10 decreases the voltage sensitivity of the inactivation channel gating (PubMed:15454437)