Homer protein homolog 2 (Homer-2) (Cupidin)
1_MGEQP 6_ IFTTR 11_ AHVFQ 16_ IDPNT 21_ KKNWM 26_ PASKQ 31_ AVTVS 36_ YFYDV 41_ TRNSY 46_ RIISV 51_ DGAKV 56_ IINST 61_ ITPNM 66_ TFTKT 71_ SQKFG 76_ QWADS 81_ RANTV 86_ FGLGF 91_ SSEQQ 96_ LTKFA 101_ EKFQE 106_ VKEAA 111_ KIAKD 116_ KTQEK 121_ IETSS 126_ NHSQE 131_ SGRET 136_ PSSTQ 141_ ASSVN 146_ GTDDE 151_ KASHA 156_ GPANT 161_ HLKSE 166_ NDKLK 171_ IALTQ 176_ SAANV 181_ KKWEI 186_ ELQTL 191_ RESNA 196_ RLTTA 201_ LQESA 206_ ASVEQ 211_ WKRQF 216_ SICRD 221_ ENDRL 226_ RNKID 231_ ELEEQ 236_ CSEIN 241_ REKEK 246_ NTQLK 251_ RRIEE 256_ LEAEL 261_ REKET 266_ ELKDL 271_ RKQSE 276_ IIPQL 281_ MSECE 286_ YVSEK 291_ LEAAE 296_ RDNQN 301_ LEDKV 306_ RSLKT 311_ DIEES 316_ KYRQR 321_ HLKVE 326_ LKSFL 331_ EVLDG 336_ KIDDL 341_ HDFRR 346_GLSKL
1: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901)