Homer protein homolog 3 (Homer-3)
1_MSTAR 6_ EQPIF 11_ STRAH 16_ VFQID 21_ PATKR 26_ NWIPA 31_ GKHAL 36_ TVSYF 41_ YDATR 46_ NVYRI 51_ ISIGG 56_ AKAII 61_ NSTVT 66_ PNMTF 71_ TKTSQ 76_ KFGQW 81_ ADSRA 86_ NTVYG 91_ LGFAS 96_ EQHLT 101_ QFAEK 106_ FQEVK 111_ EAARL 116_ AREKS 121_ QDGGE 126_ LTSPA 131_ LGLAS 136_ HQVPP 141_ SPLVS 146_ ANGPG 151_ EEKLF 156_ RSQSA 161_ DAPGP 166_ TERER 171_ LKKML 176_ SEGSV 181_ GEVQW 186_ EAEFF 191_ ALQDS 196_ NNKLA 201_ GALRE 206_ ANAAA 211_ AQWRQ 216_ QLEAQ 221_ RAEAE 226_ RLRQR 231_ VAELE 236_ AQAAS 241_ EVTPT 246_ GEKEG 251_ LGQGQ 256_ SLEQL 261_ EALVQ 266_ TKDQE 271_ IQTLK 276_ SQTGG 281_ PREAL 286_ EAAER 291_ EETQQ 296_ KVQDL 301_ ETRNA 306_ ELEHQ 311_ LRAME 316_ RSLEE 321_ ARAER 326_ ERARA 331_ EVGRA 336_ AQLLD 341_ VSLFE 346_ LSELR 351_ EGLAR 356_LAEAA
1: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901)