Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC 2.4.99.3) (GalNAc alpha-2,6-sialyltransferase I) (ST6GalNAc I) (ST6GalNAcI) (Sialyltransferase 7A) (SIAT7-A)
1_MRSCL 6_ WRCRH 11_ LSQGV 16_ QWSLL 21_ LAVLV 26_ FFLFA 31_ LPSFI 36_ KEPQT 41_ KPSRH 46_ QRTEN 51_ IKERS 56_ LQSLA 61_ KPKSQ 66_ APTRA 71_ RRTTI 76_ YAEPV 81_ PENNA 86_ LNTQT 91_ QPKAH 96_ TTGDR 101_ GKEAN 106_ QAPPE 111_ EQDKV 116_ PHTAQ 121_ RAAWK 126_ SPEKE 131_ KTMVN 136_ TLSPR 141_ GQDAG 146_ MASGR 151_ TEAQS 156_ WKSQD 161_ TKTTQ 166_ GNGGQ 171_ TRKLT 176_ ASRTV 181_ SEKHQ 186_ GKAAT 191_ TAKTL 196_ IPKSQ 201_ HRMLA 206_ PTGAV 211_ STRTR 216_ QKGVT 221_ TAVIP 226_ PKEKK 231_ PQATP 236_ PPAPF 241_ QSPTT 246_ QRNQR 251_ LKAAN 256_ FKSEP 261_ RWDFE 266_ EKYSF 271_ EIGGL 276_ QTTCP 281_ DSVKI 286_ KASKS 291_ LWLQK 296_ LFLPN 301_ LTLFL 306_ DSRHF 311_ NQSEW 316_ DRLEH 321_ FAPPF 326_ GFMEL 331_ NYSLV 336_ QKVVT 341_ RFPPV 346_ PQQQL 351_ LLASL 356_ PAGSL 361_ RCITC 366_ AVVGN 371_ GGILN 376_ NSHMG 381_ QEIDS 386_ HDYVF 391_ RLSGA 396_ LIKGY 401_ EQDVG 406_ TRTSF 411_ YGFTA 416_ FSLTQ 421_ SLLIL 426_ GNRGF 431_ KNVPL 436_ GKDVR 441_ YLHFL 446_ EGTRD 451_ YEWLE 456_ ALLMN 461_ QTVMS 466_ KNLFW 471_ FRHRP 476_ QEAFR 481_ EALHM 486_ DRYLL 491_ LHPDF 496_ LRYMK 501_ NRFLR 506_ SKTLD 511_ GAHWR 516_ IYRPT 521_ TGALL 526_ LLTAL 531_ QLCDQ 536_ VSAYG 541_ FITEG 546_ HERFS 551_ DHYYD 556_ TSWKR 561_ LIFYI 566_ NHDFK 571_ LEREV 576_ WKRLH 581_ DEGII 586_ RLYQR 591_PGPGT
1: Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis (PubMed:35303419). Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins (PubMed:10536037, PubMed:15466199, PubMed:16319059, PubMed:31719620, PubMed:35303419). Catalyzes the formation of the sialyl-Tn (S-Tn) antigen, an antigen found in intestinal goblet cells, as well as ulcerative colitis (UC) and various cancers (PubMed:15466199, PubMed:16319059, PubMed:31719620, PubMed:35303419). Protein sialylation in globlet cells is essential for mucus integrity and is required to protect the intestinal mucus against excessive bacterial proteolytic degradation (PubMed:35303419)