Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Protein G18) (Suppressor of cytokine signaling) (SOCS)
1_MVLCV 6_ QGPRP 11_ LLAVE 16_ RTGQR 21_ PLWAP 26_ SLELP 31_ KPVMQ 36_ PLPAG 41_ AFLEE 46_ VAEGT 51_ PAQTE 56_ SEPKV 61_ LDPEE 66_ DLLCI 71_ AKTFS 76_ YLRES 81_ GWYWG 86_ SITAS 91_ EARQH 96_ LQKMP 101_ EGTFL 106_ VRDST 111_ HPSYL 116_ FTLSV 121_ KTTRG 126_ PTNVR 131_ IEYAD 136_ SSFRL 141_ DSNCL 146_ SRPRI 151_ LAFPD 156_ VVSLV 161_ QHYVA 166_ SCTAD 171_ TRSDS 176_ PDPAP 181_ TPALP 186_ MPKED 191_ APSDP 196_ ALPAP 201_ PPATA 206_ VHLKL 211_ VQPFV 216_ RRSSA 221_ RSLQH 226_ LCRLV 231_ INRLV 236_ ADVDC 241_ LPLPR 246_ RMADY 251_LRQYP
1: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)