Uncharacterized protein C1orf112
1_MFLPH 6_ MNHLT 11_ LEQTF 16_ FSQVL 21_ PKTVK 26_ LFDDM 31_ MYELT 36_ SQARG 41_ LSSQN 46_ LEIQT 51_ TLRNI 56_ LQTMV 61_ QLLGA 66_ LTGCV 71_ QHICA 76_ TQESI 81_ ILENI 86_ QSLPS 91_ SVLHI 96_ IKSTF 101_ VHCKN 106_ SESVY 111_ SGCLH 116_ LVSDL 121_ LQALF 126_ KEAYS 131_ LQKQL 136_ MELLD 141_ MVCMD 146_ PLVDD 151_ NDDIL 156_ NMVIV 161_ IHSLL 166_ DICSV 171_ ISSMD 176_ HAFHA 181_ NTWKF 186_ IIKQS 191_ LKHQS 196_ IIKSQ 201_ LKHKD 206_ IITSL 211_ CEDIL 216_ FSFHS 221_ CLQLA 226_ EQMTQ 231_ SDAQD 236_ NADYR 241_ LFQKT 246_ LKLCR 251_ FFANS 256_ LLHYA 261_ KEFLP 266_ FLSDS 271_ CCTLH 276_ QLYLQ 281_ IHSKF 286_ PPSLY 291_ ATRIS 296_ KAHQE 301_ EIAGA 306_ FLVTL 311_ DPLIS 316_ QLLTF 321_ QPFMQ 326_ VVLDS 331_ KLDLP 336_ CELQF 341_ PQCLL 346_ LVVVM 351_ DKLPS 356_ QPKEV 361_ QTLWC 366_ TDSQV 371_ SETTT 376_ RISLL 381_ KAVFY 386_ SFEQC 391_ SGELS 396_ LPVHL 401_ QGLKS 406_ KGKAE 411_ VAVTL 416_ YQHVC 421_ VHLCT 426_ FITSF 431_ HPSLF 436_ AELDA 441_ ALLNA 446_ VLSAN 451_ MITSL 456_ LAMDA 461_ WCFLA 466_ RYGTA 471_ ELCAH 476_ HVTIV 481_ AHLIK 486_ SCPGE 491_ CYQLI 496_ NLSIL 501_ LKRLF 506_ FFMAP 511_ PHQLE 516_ FIQKF 521_ SPKEA 526_ ENLPL 531_ WQHIS 536_ FQALP 541_ PELRE 546_ QTVHE 551_ VTTVG 556_ TAECR 561_ KWLSR 566_ SRTLG 571_ ELESL 576_ NTVLS 581_ ALLAV 586_ CNSAG 591_ EALDT 596_ GKQTA 601_ IIEVV 606_ SQLWA 611_ FLNIK 616_ QVADQ 621_ PYVQQ 626_ TFSLL 631_ LPLLG 636_ FFIQT 641_ LDPKL 646_ ILQAV 651_ TLQTS 656_ LLKLE 661_ LPDYV 666_ RLAML 671_ DFVSS 676_ LGKLF 681_ IPEAI 686_ QDRIL 691_ PNLSC 696_ MFALL 701_ LADRS 706_ WLLEQ 711_ HTLEA 716_ FTQFA 721_ EGTNH 726_ EEIVP 731_ QCLSS 736_ EETKN 741_ KVVSF 746_ LEKTG 751_ FVDET 756_ EAAKV 761_ ERVKQ 766_ EKGIF 771_ WEPFA 776_ NVTVE 781_ EAKRS 786_ SLQPY 791_ AKRAR 796_ QEFPW 801_ EEEYR 806_ SALHT 811_ IAGAL 816_ EATES 821_ LLQKG 826_ PAPAW 831_ LSMEM 836_ EALQE 841_ RMDKL 846_KRYIH
1: Regulates PLK1 kinase activity at kinetochores and promotes faithful chromosome segregation in prometaphase by bridging kinase and phosphatase activities (PubMed:34260926). Phosphorylation of FIRRM by PLK1 negatively regulates its interaction with the phosphatase, PPP1CC, thus creating a negative feedback loop for maintaining proper PLK1 kinase activity during mitosis (PubMed:34260926). In complex with FIGL1 may regulate homologous recombination (PubMed:29608566)