SAM domain-containing protein SAMSN-1 (Hematopoietic adaptor containing SH3 and SAM domains 1) (Nash1) (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein)
1_MLKRK 6_ PSNVS 11_ EKEKH 16_ QKPKR 21_ SSSFG 26_ NFDRF 31_ RNNSL 36_ SKPDD 41_ STEAH 46_ EGDPT 51_ NGSGE 56_ QSKTS 61_ NNGGG 66_ LGKKM 71_ RAISW 76_ TMKKK 81_ VGKKY 86_ IKALS 91_ EEKDE 96_ EDGEN 101_ AHPYR 106_ NSDPV 111_ IGTHT 116_ EKVSL 121_ KASDS 126_ MDSLY 131_ SGQSS 136_ SSGIT 141_ SCSDG 146_ TSNRD 151_ SFRLD 156_ DDGPY 161_ SGPFC 166_ GRARV 171_ HTDFT 176_ PSPYD 181_ TDSLK 186_ IKKGD 191_ IIDII 196_ CKTPM 201_ GMWTG 206_ MLNNK 211_ VGNFK 216_ FIYVD 221_ VISEE 226_ EAAPK 231_ KIKAN 236_ RRSNS 241_ KKSKT 246_ LQEFL 251_ ERIHL 256_ QEYTS 261_ TLLLN 266_ GYETL 271_ EDLKD 276_ IKESH 281_ LIELN 286_ IENPD 291_ DRRRL 296_ LSAAE 301_ NFLEE 306_ EIIQE 311_ QENEP 316_ EPLSL 321_ SSDIS 326_ LNKSQ 331_ LDDCP 336_ RDSGC 341_ YISSG 346_ NSDNG 351_ KEDLE 356_ SENLS 361_ DMVHK 366_IIITE
1: Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity)