1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (EC 2.3.1.51) (Acylglycerol transacylase) (Adiponutrin) (ADPN) (Calcium-independent phospholipase A2-epsilon) (iPLA2-epsilon) (EC 3.1.1.4) (Lysophosphatidic acid acyltransferase) (Patatin-like phospholipase domain-containing protein 3) (EC 3.1.1.3)
1_MYDAE 6_ RGWSL 11_ SFAGC 16_ GFLGF 21_ YHVGA 26_ TRCLS 31_ EHAPH 36_ LLRDA 41_ RMLFG 46_ ASAGA 51_ LHCVG 56_ VLSGI 61_ PLEQT 66_ LQVLS 71_ DLVRK 76_ ARSRN 81_ IGIFH 86_ PSFNL 91_ SKFLR 96_ QGLCK 101_ CLPAN 106_ VHQLI 111_ SGKIG 116_ ISLTR 121_ VSDGE 126_ NVLVS 131_ DFRSK 136_ DEVVD 141_ ALVCS 146_ CFIPF 151_ YSGLI 156_ PPSFR 161_ GVRYV 166_ DGGVS 171_ DNVPF 176_ IDAKT 181_ TITVS 186_ PFYGE 191_ YDICP 196_ KVKST 201_ NFLHV 206_ DITKL 211_ SLRLC 216_ TGNLY 221_ LLSRA 226_ FVPPD 231_ LKVLG 236_ EICLR 241_ GYLDA 246_ FRFLE 251_ EKGIC 256_ NRPQP 261_ GLKSS 266_ SEGMD 271_ PEVAM 276_ PSWAN 281_ MSLDS 286_ SPESA 291_ ALAVR 296_ LEGDE 301_ LLDHL 306_ RLSIL 311_ PWDES 316_ ILDTL 321_ SPRLA 326_ TALSE 331_ EMKDK 336_ GGYMS 341_ KICNL 346_ LPIRI 351_ MSYVM 356_ LPCTL 361_ PVESA 366_ IAIVQ 371_ RLVTW 376_ LPDMP 381_ DDVLW 386_ LQWVT 391_ SQVFT 396_ RVLMC 401_ LLPAS 406_ RSQMP 411_ VSSQQ 416_ ASPCT 421_ PEQDW 426_ PCWTP 431_ CSPKG 436_ CPAET 441_ KAEAT 446_ PRSIL 451_ RSSLN 456_ FFLGN 461_ KVPAG 466_ AEGLS 471_ TFPSF 476_SLEKS
1: Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (PubMed:15364929, PubMed:20034933, PubMed:22560221). In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety (PubMed:21878620). However, the triacylglycerol hydrolase activity is controversial and may be very low (PubMed:22560221). Possesses phospholipase A2 activity (PubMed:15364929)