Phospholipid-transporting ATPase IB (EC 7.6.2.1) (ATPase class I type 8A member 2) (ML-1) (P4-ATPase flippase complex alpha subunit ATP8A2)
1_MLNGA 6_ GLDKA 11_ LKMSL 16_ PRRSR 21_ IRSSV 26_ GPVRS 31_ SLGYK 36_ KAEDE 41_ MSRAT 46_ SVGDQ 51_ LEAPA 56_ RTIYL 61_ NQPHL 66_ NKFRD 71_ NQIST 76_ AKYSV 81_ LTFLP 86_ RFLYE 91_ QIRRA 96_ ANAFF 101_ LFIAL 106_ LQQIP 111_ DVSPT 116_ GRYTT 121_ LVPLI 126_ IILTI 131_ AGIKE 136_ IVEDF 141_ KRHKA 146_ DNAVN 151_ KKKTI 156_ VLRNG 161_ MWHTI 166_ MWKEV 171_ AVGDI 176_ VKVVN 181_ GQYLP 186_ ADVVL 191_ LSSSE 196_ PQAMC 201_ YVETA 206_ NLDGE 211_ TNLKI 216_ RQGLS 221_ HTADM 226_ QTREV 231_ LMKLS 236_ GTIEC 241_ EGPNR 246_ HLYDF 251_ TGNLN 256_ LDGKS 261_ LVALG 266_ PDQIL 271_ LRGTQ 276_ LRNTQ 281_ WVFGI 286_ VVYTG 291_ HDTKL 296_ MQNST 301_ KAPLK 306_ RSNVE 311_ KVTNV 316_ QILVL 321_ FGILL 326_ VMALV 331_ SSAGA 336_ LYWNR 341_ SHGEK 346_ NWYIK 351_ KMDTT 356_ SDNFG 361_ YNLLT 366_ FIILY 371_ NNLIP 376_ ISLLV 381_ TLEVV 386_ KYTQA 391_ LFINW 396_ DTDMY 401_ YIGND 406_ TPAMA 411_ RTSNL 416_ NEELG 421_ QVKYL 426_ FSDKT 431_ GTLTC 436_ NIMNF 441_ KKCSI 446_ AGVTY 451_ GHFPE 456_ LAREP 461_ SSDDF 466_ CRMPP 471_ PCSDS 476_ CDFDD 481_ PRLLK 486_ NIEDR 491_ HPTAP 496_ CIQEF 501_ LTLLA 506_ VCHTV 511_ VPEKD 516_ GDNII 521_ YQASS 526_ PDEAA 531_ LVKGA 536_ KKLGF 541_ VFTAR 546_ TPFSV 551_ IIEAM 556_ GQEQT 561_ FGILN 566_ VLEFS 571_ SDRKR 576_ MSVIV 581_ RTPSG 586_ RLRLY 591_ CKGAD 596_ NVIFE 601_ RLSKD 606_ SKYME 611_ ETLCH 616_ LEYFA 621_ TEGLR 626_ TLCVA 631_ YADLS 636_ ENEYE 641_ EWLKV 646_ YQEAS 651_ TILKD 656_ RAQRL 661_ EECYE 666_ IIEKN 671_ LLLLG 676_ ATAIE 681_ DRLQA 686_ GVPET 691_ IATLL 696_ KAEIK 701_ IWVLT 706_ GDKQE 711_ TAINI 716_ GYSCR 721_ LVSQN 726_ MALIL 731_ LKEDS 736_ LDATR 741_ AAITQ 746_ HCTDL 751_ GNLLG 756_ KENDV 761_ ALIID 766_ GHTLK 771_ YALSF 776_ EVRRS 781_ FLDLA 786_ LSCKA 791_ VICCR 796_ VSPLQ 801_ KSEIV 806_ DVVKK 811_ RVKAI 816_ TLAIG 821_ DGAND 826_ VGMIQ 831_ TAHVG 836_ VGISG 841_ NEGMQ 846_ ATNNS 851_ DYAIA 856_ QFSYL 861_ EKLLL 866_ VHGAW 871_ SYNRV 876_ TKCIL 881_ YCFYK 886_ NVVLY 891_ IIELW 896_ FAFVN 901_ GFSGQ 906_ ILFER 911_ WCIGL 916_ YNVIF 921_ TALPP 926_ FTLGI 931_ FERSC 936_ TQESM 941_ LRFPQ 946_ LYKIT 951_ QNGEG 956_ FNTKV 961_ FWGHC 966_ INALV 971_ HSLIL 976_ FWFPM 981_ KALEH 986_ DTVLT 991_ SGHAT 996_ DYLFV 1001_ GNIVY 1006_ TYVVV 1011_ TVCLK 1016_ AGLET 1021_ TAWTK 1026_ FSHLA 1031_ VWGSM 1036_ LTWLV 1041_ FFGIY 1046_ STIWP 1051_ TIPIA 1056_ PDMRG 1061_ QATMV 1066_ LSSAH 1071_ FWLGL 1076_ FLVPT 1081_ ACLIE 1086_ DVAWR 1091_ AAKHT 1096_ CKKTL 1101_ LEEVQ 1106_ ELETK 1111_ SRVLG 1116_ KAVLR 1121_ DSNGK 1126_ RLNER 1131_ DRLIK 1136_ RLGRK 1141_ TPPTL 1146_ FRGSS 1151_ LQQGV 1156_ PHGYA 1161_ FSQEE 1166_ HGAVS 1171_ QEEVI 1176_ RAYDT 1181_TKKKS
1: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (By similarity). Able to translocate phosphatidylserine, but not phosphatidylcholine (PubMed:34403372). Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity). Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (By similarity). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (By similarity). ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth (By similarity). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes (By similarity). May be involved in vesicle trafficking in neuronal cells (By similarity). Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival (By similarity)