Phosphatidylinositol-3-phosphatase SAC1 (EC 3.1.3.64) (Phosphatidylinositol-4-phosphate phosphatase) (Suppressor of actin mutations 1-like protein)
1_MATAA 6_ YEQLK 11_ LHITP 16_ EKFYV 21_ EACDD 26_ GADDV 31_ LTIDR 36_ VSTEV 41_ TLAVK 46_ KDVPP 51_ SAVTR 56_ PIFGI 61_ LGTIH 66_ LVAGN 71_ YLIVI 76_ TKKIK 81_ VGEFF 86_ SHVVW 91_ KATDF 96_ DVLSY 101_ KKTML 106_ HLTDI 111_ QLQDN 116_ KTFLA 121_ MLNHV 126_ LNVDG 131_ FYFST 136_ TYDLT 141_ HTLQR 146_ LSNTS 151_ PEFQE 156_ MSLLE 161_ RADQR 166_ FVWNG 171_ HLLRE 176_ LSAQP 181_ EVHRF 186_ ALPVL 191_ HGFIT 196_ MHSCS 201_ INGKY 206_ FDWIL 211_ ISRRS 216_ CFRAG 221_ VRYYV 226_ RGIDS 231_ EGHAA 236_ NFVET 241_ EQIVH 246_ YNGSK 251_ ASFVQ 256_ TRGSI 261_ PVFWS 266_ QRPNL 271_ KYKPL 276_ PQISK 281_ VANHM 286_ DGFQR 291_ HFDSQ 296_ VIIYG 301_ KQVII 306_ NLINQ 311_ KGSEK 316_ PLEQT 321_ FATMV 326_ SSLGS 331_ GMMRY 336_ IAFDF 341_ HKECK 346_ NMRWD 351_ RLSIL 356_ LDQVA 361_ EMQDE 366_ LSYFL 371_ VDSAG 376_ QVVAN 381_ QEGVF 386_ RSNCM 391_ DCLDR 396_ TNVIQ 401_ SLLAR 406_ RSLQA 411_ QLQRL 416_ GVLHV 421_ GQKLE 426_ EQDEF 431_ EKIYK 436_ NAWAD 441_ NANAC 446_ AKQYA 451_ GTGAL 456_ KTDFT 461_ RTGKR 466_ THLGL 471_ IMDGW 476_ NSMIR 481_ YYKNN 486_ FSDGF 491_ RQDSI 496_ DLFLG 501_ NYSVD 506_ ELESH 511_ SPLSV 516_ PRDWK 521_ FLALP 526_ IIMVV 531_ AFSMC 536_ IICLL 541_ MAGDT 546_ WTETL 551_ AYVLF 556_ WGVAS 561_ IGTFF 566_ IILYN 571_ GKDFV 576_ DAPRL 581_VQKEK
1: Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:24209621, PubMed:27044890, PubMed:29461204, PubMed:30659099). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (PubMed:24209621, PubMed:29461204, PubMed:30659099). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (PubMed:30659099)