UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter (UDP-GlcA/UDP-GalNAc transporter) (Solute carrier family 35 member D1) (UDP-galactose transporter-related protein 7) (UGTrel7)
1_MAEVH 6_ RRQHA 11_ RVKGE 16_ APAKS 21_ STLRD 26_ EEELG 31_ MASAE 36_ TLTVF 41_ LKLLA 46_ AGFYG 51_ VSSFL 56_ IVVVN 61_ KSVLT 66_ NYRFP 71_ SSLCV 76_ GLGQM 81_ VATVA 86_ VLWVG 91_ KALRV 96_ VKFPD 101_ LDRNV 106_ PRKTF 111_ PLPLL 116_ YFGNQ 121_ ITGLF 126_ STKKL 131_ NLPMF 136_ TVLRR 141_ FSILF 146_ TMFAE 151_ GVLLK 156_ KTFSW 161_ GIKMT 166_ VFAMI 171_ IGAFV 176_ AASSD 181_ LAFDL 186_ EGYAF 191_ ILIND 196_ VLTAA 201_ NGAYV 206_ KQKLD 211_ SKELG 216_ KYGLL 221_ YYNAL 226_ FMILP 231_ TLAIA 236_ YFTGD 241_ AQKAV 246_ EFEGW 251_ ADTLF 256_ LLQFT 261_ LSCVM 266_ GFILM 271_ YATVL 276_ CTQYN 281_ SALTT 286_ TIVGC 291_ IKNIL 296_ ITYIG 301_ MVFGG 306_ DYIFT 311_ WTNFI 316_ GLNIS 321_ IAGSL 326_ VYSYI 331_ TFTEE 336_ QLSKQ 341_ SEANN 346_KLDIK
1: Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for either their cognate nucleoside monophosphate or another nucleotide sugar (PubMed:16965264, PubMed:17599910, PubMed:31423530). Transports various UDP-sugars including UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc), UDP-N-acetyl-alpha-D-galactosamine (UDP-GalNAc) and UDP-alpha-D-glucuronate (UDP-GlcA), which are used by ER glucosyltransferases as sugar donors for the synthesis of sugar chains of glycoproteins, glycolipids and oligosaccharides (PubMed:11322953, PubMed:16965264, PubMed:17599910, PubMed:17952091, PubMed:31423530). May couple UDP-GlcNAc or UDP-GalNAc efflux to UDP-GlcA influx into the ER lumen that in turn stimulates glucuronidation and subsequent excretion of endobiotics and xenobiotics (PubMed:16965264, PubMed:17599910). Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity)